Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and Adsorption
Crimean-Congo hemorrhagic fever (CCHF) is a viral hemorrhagic fever syndrome that can cause multi-organ failure with hyperactivation of the immune system. There is no proven treatment for CCHF, supportive care is essential for management. Extracorporeal depurative techniques have been used to remove...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-09-01
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| Series: | Türk Yoğun Bakim Derneği Dergisi |
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http://www.turkishjic.org/archives/archive-detail/article-preview/alternative-treatment-method-for-crimean-congo-hem/62184
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| author | Dilşat Tepe Gürdal Yılmaz Ahmet Oğuzhan Küçük Mehtap Pehlivanlar Küçük |
| author_facet | Dilşat Tepe Gürdal Yılmaz Ahmet Oğuzhan Küçük Mehtap Pehlivanlar Küçük |
| author_sort | Dilşat Tepe |
| collection | DOAJ |
| description | Crimean-Congo hemorrhagic fever (CCHF) is a viral hemorrhagic fever syndrome that can cause multi-organ failure with hyperactivation of the immune system. There is no proven treatment for CCHF, supportive care is essential for management. Extracorporeal depurative techniques have been used to remove inflammatory mediators from the bloodstream. This report aims to present the use of coupled plasma filtration and adsorption (CPFA) in CCHF patients. We performed CPFA on three patients with CCHF, all of which were confirmed with polymerase chain reaction. A 35-year-old female was admitted one week after tick-exposure. Despite supportive treatment, patient developed mucosal and gastrointestinal bleeding due to disseminated intravascular coagulation (DIC). After CFPA, her clinic situation and laboratory results improved. A 54-year-old female was admitted to the intensive care unit due to severe bleeding and had a history of tick bite nine-days-ago. She had multiple organ failure with DIC, we started CPFA. Patient didn’t respond to the treatment and died. A 69-year-old male was admitted to the hospital on the seventh-day of exposure to tick. He had diabetes, hypertension and coronary artery disease. Next day, patient developed alveolar hemorrhage and his liver enzymes, coagulation parameters deteriorated. We performed CFPA, however, the patient didn’t respond to treatment and died. We suggested that CPFA may have positive effects on the outcome and prognosis of critically ill CCHF patients. Only one patient responded well which can be a result of being young, early admission to the hospital and lack of comorbidity. CPFA may be an option to treat severe CCHF infection with cytokine storm. However,there is a need for further studies on when we should apply this treatment and whether early application prevents mortality. |
| first_indexed | 2024-03-11T21:44:21Z |
| format | Article |
| id | doaj.art-2f79f947b5fa42a2b0086eb16819dd44 |
| institution | Directory Open Access Journal |
| issn | 2146-6416 2147-267X |
| language | English |
| last_indexed | 2024-03-11T21:44:21Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Yoğun Bakim Derneği Dergisi |
| spelling | doaj.art-2f79f947b5fa42a2b0086eb16819dd442023-09-26T10:48:07ZengGalenos YayineviTürk Yoğun Bakim Derneği Dergisi2146-64162147-267X2023-09-0121323423810.4274/tybd.galenos.2023.2886313049054Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and AdsorptionDilşat Tepe0Gürdal Yılmaz1Ahmet Oğuzhan Küçük2Mehtap Pehlivanlar Küçük3 Karadeniz Technical University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, Turkey Karadeniz Technical University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, Turkey Karadeniz Technical University Faculty of Medicine, Department of Pulmonary Medicine, Division of Intensive Care, Trabzon, Turkey Karadeniz Technical University Faculty of Medicine, Department of Pulmonary Medicine, Division of Intensive Care, Trabzon, Turkey Crimean-Congo hemorrhagic fever (CCHF) is a viral hemorrhagic fever syndrome that can cause multi-organ failure with hyperactivation of the immune system. There is no proven treatment for CCHF, supportive care is essential for management. Extracorporeal depurative techniques have been used to remove inflammatory mediators from the bloodstream. This report aims to present the use of coupled plasma filtration and adsorption (CPFA) in CCHF patients. We performed CPFA on three patients with CCHF, all of which were confirmed with polymerase chain reaction. A 35-year-old female was admitted one week after tick-exposure. Despite supportive treatment, patient developed mucosal and gastrointestinal bleeding due to disseminated intravascular coagulation (DIC). After CFPA, her clinic situation and laboratory results improved. A 54-year-old female was admitted to the intensive care unit due to severe bleeding and had a history of tick bite nine-days-ago. She had multiple organ failure with DIC, we started CPFA. Patient didn’t respond to the treatment and died. A 69-year-old male was admitted to the hospital on the seventh-day of exposure to tick. He had diabetes, hypertension and coronary artery disease. Next day, patient developed alveolar hemorrhage and his liver enzymes, coagulation parameters deteriorated. We performed CFPA, however, the patient didn’t respond to treatment and died. We suggested that CPFA may have positive effects on the outcome and prognosis of critically ill CCHF patients. Only one patient responded well which can be a result of being young, early admission to the hospital and lack of comorbidity. CPFA may be an option to treat severe CCHF infection with cytokine storm. However,there is a need for further studies on when we should apply this treatment and whether early application prevents mortality. http://www.turkishjic.org/archives/archive-detail/article-preview/alternative-treatment-method-for-crimean-congo-hem/62184 crimean-congo hemorrhagic fevertherapeutic plasma adsorptiontherapeutic plasmapheresis |
| spellingShingle | Dilşat Tepe Gürdal Yılmaz Ahmet Oğuzhan Küçük Mehtap Pehlivanlar Küçük Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and Adsorption Türk Yoğun Bakim Derneği Dergisi crimean-congo hemorrhagic fever therapeutic plasma adsorption therapeutic plasmapheresis |
| title | Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and Adsorption |
| title_full | Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and Adsorption |
| title_fullStr | Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and Adsorption |
| title_full_unstemmed | Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and Adsorption |
| title_short | Alternative Treatment Method for Crimean Congo Hemorrhagic Fever: Coupled Plasma Filtration and Adsorption |
| title_sort | alternative treatment method for crimean congo hemorrhagic fever coupled plasma filtration and adsorption |
| topic | crimean-congo hemorrhagic fever therapeutic plasma adsorption therapeutic plasmapheresis |
| url |
http://www.turkishjic.org/archives/archive-detail/article-preview/alternative-treatment-method-for-crimean-congo-hem/62184
|
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