Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling
Rutin is the rutinose conjugate of quercetin. It presents several biological activities and is the major flavonoid in the hydroalcoholic extract of the calyces of <i>Physalis peruviana</i> L. It also shows hypoglycemic activity after oral administration. The aim of this work was to study...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/4/535 |
| _version_ | 1797537976047108096 |
|---|---|
| author | Gina Paola Domínguez Moré María Isabel Cardona Paula Michelle Sepúlveda Sandra Milena Echeverry Cláudia Maria Oliveira Simões Diana Marcela Aragón |
| author_facet | Gina Paola Domínguez Moré María Isabel Cardona Paula Michelle Sepúlveda Sandra Milena Echeverry Cláudia Maria Oliveira Simões Diana Marcela Aragón |
| author_sort | Gina Paola Domínguez Moré |
| collection | DOAJ |
| description | Rutin is the rutinose conjugate of quercetin. It presents several biological activities and is the major flavonoid in the hydroalcoholic extract of the calyces of <i>Physalis peruviana</i> L. It also shows hypoglycemic activity after oral administration. The aim of this work was to study the matrix effects of the extract from <i>P. peruviana</i> calyces on the pharmacokinetics of rutin and its metabolites in Wistar rats, using non-compartmental and population pharmacokinetic analyses. A pharmacokinetic study was performed after intravenous and oral administration of different doses of pure rutin and the extract. In the non-compartmental analysis, it was found that rutin from the extract exhibited higher distribution and clearance, as well as an 11-fold increase in the bioavailability of its active metabolites. A population pharmacokinetic model was also carried out with two compartments, double absorption and linear elimination, in which the extract and the doses were the covariates involved. This model correctly described the differences observed between rutin as a pure compound and rutin from the extract, including the dose dependency. |
| first_indexed | 2024-03-10T12:23:53Z |
| format | Article |
| id | doaj.art-2f7b0831b76f4c059317a7dc185d1f3e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T12:23:53Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-2f7b0831b76f4c059317a7dc185d1f3e2023-11-21T15:12:43ZengMDPI AGPharmaceutics1999-49232021-04-0113453510.3390/pharmaceutics13040535Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population ModelingGina Paola Domínguez Moré0María Isabel Cardona1Paula Michelle Sepúlveda2Sandra Milena Echeverry3Cláudia Maria Oliveira Simões4Diana Marcela Aragón5Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 11011, ColombiaDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 11011, ColombiaDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 11011, ColombiaDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 11011, ColombiaPrograma de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina—UFSC, Florianópolis 88040-970, BrazilDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 11011, ColombiaRutin is the rutinose conjugate of quercetin. It presents several biological activities and is the major flavonoid in the hydroalcoholic extract of the calyces of <i>Physalis peruviana</i> L. It also shows hypoglycemic activity after oral administration. The aim of this work was to study the matrix effects of the extract from <i>P. peruviana</i> calyces on the pharmacokinetics of rutin and its metabolites in Wistar rats, using non-compartmental and population pharmacokinetic analyses. A pharmacokinetic study was performed after intravenous and oral administration of different doses of pure rutin and the extract. In the non-compartmental analysis, it was found that rutin from the extract exhibited higher distribution and clearance, as well as an 11-fold increase in the bioavailability of its active metabolites. A population pharmacokinetic model was also carried out with two compartments, double absorption and linear elimination, in which the extract and the doses were the covariates involved. This model correctly described the differences observed between rutin as a pure compound and rutin from the extract, including the dose dependency.https://www.mdpi.com/1999-4923/13/4/535rutinpharmacokineticspopulation pharmacokinetic modelingextract<i>Physalis peruviana</i> |
| spellingShingle | Gina Paola Domínguez Moré María Isabel Cardona Paula Michelle Sepúlveda Sandra Milena Echeverry Cláudia Maria Oliveira Simões Diana Marcela Aragón Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling Pharmaceutics rutin pharmacokinetics population pharmacokinetic modeling extract <i>Physalis peruviana</i> |
| title | Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling |
| title_full | Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling |
| title_fullStr | Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling |
| title_full_unstemmed | Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling |
| title_short | Matrix Effects of the Hydroethanolic Extract of Calyces of <i>Physalis peruviana</i> L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling |
| title_sort | matrix effects of the hydroethanolic extract of calyces of i physalis peruviana i l on rutin pharmacokinetics in wistar rats using population modeling |
| topic | rutin pharmacokinetics population pharmacokinetic modeling extract <i>Physalis peruviana</i> |
| url | https://www.mdpi.com/1999-4923/13/4/535 |
| work_keys_str_mv | AT ginapaoladominguezmore matrixeffectsofthehydroethanolicextractofcalycesofiphysalisperuvianailonrutinpharmacokineticsinwistarratsusingpopulationmodeling AT mariaisabelcardona matrixeffectsofthehydroethanolicextractofcalycesofiphysalisperuvianailonrutinpharmacokineticsinwistarratsusingpopulationmodeling AT paulamichellesepulveda matrixeffectsofthehydroethanolicextractofcalycesofiphysalisperuvianailonrutinpharmacokineticsinwistarratsusingpopulationmodeling AT sandramilenaecheverry matrixeffectsofthehydroethanolicextractofcalycesofiphysalisperuvianailonrutinpharmacokineticsinwistarratsusingpopulationmodeling AT claudiamariaoliveirasimoes matrixeffectsofthehydroethanolicextractofcalycesofiphysalisperuvianailonrutinpharmacokineticsinwistarratsusingpopulationmodeling AT dianamarcelaaragon matrixeffectsofthehydroethanolicextractofcalycesofiphysalisperuvianailonrutinpharmacokineticsinwistarratsusingpopulationmodeling |