The role of dendritic cells derived osteoclasts in bone destruction diseases
The bone is previously considered as a dominant organ involved in the processes of locomotion. However, in the past two decades, a large number of studies have suggested that the skeletal system closely coordinated with the immune system so as to result in the emerging area of ‘osteoimmunology’. In...
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KeAi Communications Co., Ltd.
2021-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304220300519 |
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| author | Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong |
| author_facet | Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong |
| author_sort | Bo Wang |
| collection | DOAJ |
| description | The bone is previously considered as a dominant organ involved in the processes of locomotion. However, in the past two decades, a large number of studies have suggested that the skeletal system closely coordinated with the immune system so as to result in the emerging area of ‘osteoimmunology’. In the evolution of many kinds of bone destruction-related diseases, osteoclasts could differentiate from dendritic cells, which contributed to increased expression of osteoclast-related membrane receptors and relatively higher activity of bone destruction, inducing severe bone destruction under inflammatory conditions. Numerous factors could influence the interaction between osteoclasts and dendritic cells, contributing to the pathogenesis of several bone diseases in the context of inflammation, including both immunocytes and a large number of cytokines. In addition, the products of osteoclasts released from bone destruction area serve as important signals for the differentiation and activation of immature dendritic cells. Therefore, the border between the dendritic cell-related immune response and osteoclast-related bone destruction has gradually unravelled. Dendritic cells and osteoclasts cooperate with each other to mediate bone destruction and bone remodelling under inflammatory conditions. In this review, we will pay attention to the interactions between dendritic cells and osteoclasts in physiological and pathological conditions to further understand the skeletal system and identify potential new therapeutic targets for the future by summarizing their significant roles and molecular mechanisms in bone destruction. |
| first_indexed | 2024-03-12T07:31:00Z |
| format | Article |
| id | doaj.art-2f7d3f4f88624351b408703893bf8e20 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T07:31:00Z |
| publishDate | 2021-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-2f7d3f4f88624351b408703893bf8e202023-09-02T21:47:43ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-07-0184401411The role of dendritic cells derived osteoclasts in bone destruction diseasesBo Wang0Yutong Dong1Zhansong Tian2Yueqi Chen3Shiwu Dong4Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China; Battalion of Basic Medical Sciences, Third Military Medical University (Army Medical University), Chongqing, 400038, PR ChinaDepartment of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China; Battalion of Basic Medical Sciences, Third Military Medical University (Army Medical University), Chongqing, 400038, PR ChinaDepartment of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, PR ChinaDepartment of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China; Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China; Corresponding author. Department of Biomedical Materials Science, Department of Orthopedics, Southwest Hospital, Third military medical university (Army Medical University), Gaotanyan Street No.30, Chongqing, 400038, China.Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China; Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China; State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China; Corresponding author. Department of Biomedical Materials Science, School of Biomedical Engineering, Third military medical university (Army Medical University), Gaotanyan Street No.30, Chongqing, 400038, China.The bone is previously considered as a dominant organ involved in the processes of locomotion. However, in the past two decades, a large number of studies have suggested that the skeletal system closely coordinated with the immune system so as to result in the emerging area of ‘osteoimmunology’. In the evolution of many kinds of bone destruction-related diseases, osteoclasts could differentiate from dendritic cells, which contributed to increased expression of osteoclast-related membrane receptors and relatively higher activity of bone destruction, inducing severe bone destruction under inflammatory conditions. Numerous factors could influence the interaction between osteoclasts and dendritic cells, contributing to the pathogenesis of several bone diseases in the context of inflammation, including both immunocytes and a large number of cytokines. In addition, the products of osteoclasts released from bone destruction area serve as important signals for the differentiation and activation of immature dendritic cells. Therefore, the border between the dendritic cell-related immune response and osteoclast-related bone destruction has gradually unravelled. Dendritic cells and osteoclasts cooperate with each other to mediate bone destruction and bone remodelling under inflammatory conditions. In this review, we will pay attention to the interactions between dendritic cells and osteoclasts in physiological and pathological conditions to further understand the skeletal system and identify potential new therapeutic targets for the future by summarizing their significant roles and molecular mechanisms in bone destruction.http://www.sciencedirect.com/science/article/pii/S2352304220300519Bone destruction diseasesDendritic cellsOsteoclastsOsteoimmunologyTrans-differentiation |
| spellingShingle | Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong The role of dendritic cells derived osteoclasts in bone destruction diseases Genes and Diseases Bone destruction diseases Dendritic cells Osteoclasts Osteoimmunology Trans-differentiation |
| title | The role of dendritic cells derived osteoclasts in bone destruction diseases |
| title_full | The role of dendritic cells derived osteoclasts in bone destruction diseases |
| title_fullStr | The role of dendritic cells derived osteoclasts in bone destruction diseases |
| title_full_unstemmed | The role of dendritic cells derived osteoclasts in bone destruction diseases |
| title_short | The role of dendritic cells derived osteoclasts in bone destruction diseases |
| title_sort | role of dendritic cells derived osteoclasts in bone destruction diseases |
| topic | Bone destruction diseases Dendritic cells Osteoclasts Osteoimmunology Trans-differentiation |
| url | http://www.sciencedirect.com/science/article/pii/S2352304220300519 |
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