A current review on animal models of anti-hypertensive drugs screening
One of the main contributors to death or disability from heart attack, stroke, and renal failure is hypertension. Experimental animal models have been extremely useful in learning more about the aetiology, pathophysiology, consequences, and treatment of hypertension and antihypertensive drugs are ev...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Health Sciences Review |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772632023000041 |
| _version_ | 1827987771161051136 |
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| author | Mehvish Bhat Mohammad Zaid Shivam Singh Kartik Gill Junaid Tantray Rajesh Kumar Sharma Mithilesh Singh Anurag Mishra Ravindra Pal Singh Sanjay Kumar Sahu Arun Garg Ashish Kumar Sharma |
| author_facet | Mehvish Bhat Mohammad Zaid Shivam Singh Kartik Gill Junaid Tantray Rajesh Kumar Sharma Mithilesh Singh Anurag Mishra Ravindra Pal Singh Sanjay Kumar Sahu Arun Garg Ashish Kumar Sharma |
| author_sort | Mehvish Bhat |
| collection | DOAJ |
| description | One of the main contributors to death or disability from heart attack, stroke, and renal failure is hypertension. Experimental animal models have been extremely useful in learning more about the aetiology, pathophysiology, consequences, and treatment of hypertension and antihypertensive drugs are evaluated. There are several strains of genetically hypertensive rats available today, and most laboratories use these models to conduct therapeutic studies on hypertension. Both traditional and genetic models of hypertension animal models, their characteristics, and their significance are summarized as: In-Vitro Animal Models: Antagonism of Endothelin Receptors in Porcine Isolated Hearts and Monocrotaline induced pulmonary Hypertension. In-Vivo Animal Models: Rat Hypertension Models One-Kidney-Two Clip (Goldblatt hypertension, 2K1C), Rats with Chronic Renal Hypertension (1-kidney-1-clip method), Pithed rats blood pressure, Tail Cuff in rats, Blood pressure measurements using an ingestible catheter in conscious rats, Dahl salt-sensitive rat model, Model of Fructose- induced Hypertension in rats, DOCO Salt rats, Spontaneously Hypertensive Rats, Transgenic Rats Overexpressing Mouse Ren2 Gene (TGR (mRen 2) 27), Models of hypertension in dogs (Renal Chronic Hypertension), Neurogenic hypertension, Hypertension model of a monkey (Inhibition of renin in monkeys), Hypertension transgenic models and Hypertension by chronic inhibition of nitric oxide. Conclusion: In this article, experimental models of hypertension, traditional and genetic gives quick summary of the most popular animal models, their characteristics, and their significance. |
| first_indexed | 2024-04-09T23:53:18Z |
| format | Article |
| id | doaj.art-2f7d7c826cd04dac8b9cbe867ac350a5 |
| institution | Directory Open Access Journal |
| issn | 2772-6320 |
| language | English |
| last_indexed | 2024-04-09T23:53:18Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Health Sciences Review |
| spelling | doaj.art-2f7d7c826cd04dac8b9cbe867ac350a52023-03-17T04:35:05ZengElsevierHealth Sciences Review2772-63202023-03-016100078A current review on animal models of anti-hypertensive drugs screeningMehvish Bhat0Mohammad Zaid1Shivam Singh2Kartik Gill3Junaid Tantray4Rajesh Kumar Sharma5Mithilesh Singh6Anurag Mishra7Ravindra Pal Singh8Sanjay Kumar Sahu9Arun Garg10Ashish Kumar Sharma11NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaFormulation & Development-R&D, Medley Pharmaceuticals Ltd., Mumbai IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 IndiaNIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 India; Corresponding author at: NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, Rajasthan 303121 India.One of the main contributors to death or disability from heart attack, stroke, and renal failure is hypertension. Experimental animal models have been extremely useful in learning more about the aetiology, pathophysiology, consequences, and treatment of hypertension and antihypertensive drugs are evaluated. There are several strains of genetically hypertensive rats available today, and most laboratories use these models to conduct therapeutic studies on hypertension. Both traditional and genetic models of hypertension animal models, their characteristics, and their significance are summarized as: In-Vitro Animal Models: Antagonism of Endothelin Receptors in Porcine Isolated Hearts and Monocrotaline induced pulmonary Hypertension. In-Vivo Animal Models: Rat Hypertension Models One-Kidney-Two Clip (Goldblatt hypertension, 2K1C), Rats with Chronic Renal Hypertension (1-kidney-1-clip method), Pithed rats blood pressure, Tail Cuff in rats, Blood pressure measurements using an ingestible catheter in conscious rats, Dahl salt-sensitive rat model, Model of Fructose- induced Hypertension in rats, DOCO Salt rats, Spontaneously Hypertensive Rats, Transgenic Rats Overexpressing Mouse Ren2 Gene (TGR (mRen 2) 27), Models of hypertension in dogs (Renal Chronic Hypertension), Neurogenic hypertension, Hypertension model of a monkey (Inhibition of renin in monkeys), Hypertension transgenic models and Hypertension by chronic inhibition of nitric oxide. Conclusion: In this article, experimental models of hypertension, traditional and genetic gives quick summary of the most popular animal models, their characteristics, and their significance.http://www.sciencedirect.com/science/article/pii/S2772632023000041Heart attackStrokeRenal failureAetiologyPathophysiologyPulmonary hypertension |
| spellingShingle | Mehvish Bhat Mohammad Zaid Shivam Singh Kartik Gill Junaid Tantray Rajesh Kumar Sharma Mithilesh Singh Anurag Mishra Ravindra Pal Singh Sanjay Kumar Sahu Arun Garg Ashish Kumar Sharma A current review on animal models of anti-hypertensive drugs screening Health Sciences Review Heart attack Stroke Renal failure Aetiology Pathophysiology Pulmonary hypertension |
| title | A current review on animal models of anti-hypertensive drugs screening |
| title_full | A current review on animal models of anti-hypertensive drugs screening |
| title_fullStr | A current review on animal models of anti-hypertensive drugs screening |
| title_full_unstemmed | A current review on animal models of anti-hypertensive drugs screening |
| title_short | A current review on animal models of anti-hypertensive drugs screening |
| title_sort | current review on animal models of anti hypertensive drugs screening |
| topic | Heart attack Stroke Renal failure Aetiology Pathophysiology Pulmonary hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S2772632023000041 |
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