Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population
Elderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed. We conducted a biphasic prospective, populat...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-07-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1299300 |
| _version_ | 1797677600594722816 |
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| author | Manas K. Akmatov Peggy Riese Marcus May Leonhard Jentsch Malik W. Ahmed Damaris Werner Anja Rösel Megan Tyler Kevin Pessler Jana Prokein Inga Bernemann Norman Klopp Blair Prochnow Stephanie Trittel Aravind Tallam Thomas Illig Christoph Schindler Carlos A. Guzmán Frank Pessler |
| author_facet | Manas K. Akmatov Peggy Riese Marcus May Leonhard Jentsch Malik W. Ahmed Damaris Werner Anja Rösel Megan Tyler Kevin Pessler Jana Prokein Inga Bernemann Norman Klopp Blair Prochnow Stephanie Trittel Aravind Tallam Thomas Illig Christoph Schindler Carlos A. Guzmán Frank Pessler |
| author_sort | Manas K. Akmatov |
| collection | DOAJ |
| description | Elderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed. We conducted a biphasic prospective, population-based study from Dec. 2014 to May 2015 (pilot study) and Sept. 2015 to May 2016 (main study). Individuals 65–80 y of age were randomly selected from the residents' registration office in Hannover, Germany, for the pilot (n = 34) and main study (n = 200). The pilot study tested recruitment for study arms featuring 2, 4, or 5 visits/blood draws. The 5-visit (day 0, 1/3, 7, 21, 70 with respect to vaccination) study arm was selected for the main study. Both studies featured vaccination with Fluad™ (Novartis, Italy), a detailed medical history, a physical exam, recording of adverse events, completion of a questionnaire on common infections and an end-of-study questionnaire, and blood samples. Response rates in the pilot and main studies were 3.7% and 4.0%, respectively. Willingness to participate did not differ among the study arms (Fisher's exact test, p = 0.44). In both studies, there were no losses to follow-up. Compliance with study visits, blood sampling and completion of the questionnaires was very high (100%, >97%, 100%, respectively), as were participants' acceptance of and satisfaction with both phases of the study. The low response rates indicate the need for optimized recruitment strategies if the study population is to be representative of the general population. Nonetheless, the complex prospective study design proved to be highly feasible. |
| first_indexed | 2024-03-11T22:47:37Z |
| format | Article |
| id | doaj.art-2f7e0859e8cd42408bf1441a2939e166 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:47:37Z |
| publishDate | 2017-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-2f7e0859e8cd42408bf1441a2939e1662023-09-22T08:17:49ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-07-011371630163910.1080/21645515.2017.12993001299300Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general populationManas K. Akmatov0Peggy Riese1Marcus May2Leonhard Jentsch3Malik W. Ahmed4Damaris Werner5Anja Rösel6Megan Tyler7Kevin Pessler8Jana Prokein9Inga Bernemann10Norman Klopp11Blair Prochnow12Stephanie Trittel13Aravind Tallam14Thomas Illig15Christoph Schindler16Carlos A. Guzmán17Frank Pessler18TWINCORE, Centre for Experimental and Clinical Infection ResearchHelmholtz Centre for Infection ResearchHannover Medical SchoolTWINCORE, Centre for Experimental and Clinical Infection ResearchTWINCORE, Centre for Experimental and Clinical Infection ResearchTWINCORE, Centre for Experimental and Clinical Infection ResearchTWINCORE, Centre for Experimental and Clinical Infection ResearchHannover Medical SchoolTWINCORE, Centre for Experimental and Clinical Infection ResearchHannover Medical SchoolHannover Medical SchoolHannover Medical SchoolHelmholtz Centre for Infection ResearchHelmholtz Centre for Infection ResearchTWINCORE, Centre for Experimental and Clinical Infection ResearchHannover Medical SchoolHannover Medical SchoolCentre for Individualized Infection MedicineTWINCORE, Centre for Experimental and Clinical Infection ResearchElderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed. We conducted a biphasic prospective, population-based study from Dec. 2014 to May 2015 (pilot study) and Sept. 2015 to May 2016 (main study). Individuals 65–80 y of age were randomly selected from the residents' registration office in Hannover, Germany, for the pilot (n = 34) and main study (n = 200). The pilot study tested recruitment for study arms featuring 2, 4, or 5 visits/blood draws. The 5-visit (day 0, 1/3, 7, 21, 70 with respect to vaccination) study arm was selected for the main study. Both studies featured vaccination with Fluad™ (Novartis, Italy), a detailed medical history, a physical exam, recording of adverse events, completion of a questionnaire on common infections and an end-of-study questionnaire, and blood samples. Response rates in the pilot and main studies were 3.7% and 4.0%, respectively. Willingness to participate did not differ among the study arms (Fisher's exact test, p = 0.44). In both studies, there were no losses to follow-up. Compliance with study visits, blood sampling and completion of the questionnaires was very high (100%, >97%, 100%, respectively), as were participants' acceptance of and satisfaction with both phases of the study. The low response rates indicate the need for optimized recruitment strategies if the study population is to be representative of the general population. Nonetheless, the complex prospective study design proved to be highly feasible.http://dx.doi.org/10.1080/21645515.2017.1299300elderlyfeasibilityinfluenza vaccinationnonresponse biaspilot studypopulation-based studyresponse ratevaccinomicsgermany |
| spellingShingle | Manas K. Akmatov Peggy Riese Marcus May Leonhard Jentsch Malik W. Ahmed Damaris Werner Anja Rösel Megan Tyler Kevin Pessler Jana Prokein Inga Bernemann Norman Klopp Blair Prochnow Stephanie Trittel Aravind Tallam Thomas Illig Christoph Schindler Carlos A. Guzmán Frank Pessler Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population Human Vaccines & Immunotherapeutics elderly feasibility influenza vaccination nonresponse bias pilot study population-based study response rate vaccinomics germany |
| title | Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population |
| title_full | Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population |
| title_fullStr | Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population |
| title_full_unstemmed | Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population |
| title_short | Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population |
| title_sort | establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population |
| topic | elderly feasibility influenza vaccination nonresponse bias pilot study population-based study response rate vaccinomics germany |
| url | http://dx.doi.org/10.1080/21645515.2017.1299300 |
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