Boosting regulatory T cell function by CD4 stimulation enters the clinic

Boosting regulatory T cell function by CD4 stimulation enters the clinic

Understanding tolerance mechanisms at the cellular and molecular level holds the promise to establish novel immune intervention therapies in patients with allergy or autoimmunity and to prevent transplant rejection. Administration of monoclonal antibodies (mAb) against the CD4 molecule has been foun...

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Bibliographic Details
Main Authors: Christian eBecker, Tobias eBopp, Helmut eJonuleit
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Immunology
Subjects:
Monoclonal antibody
tolerance
regulatory T cells
cAMP
anti-CD4
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00164/full

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