Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide
Short peptides containing the Arg-Gly-Asp (RGD) fragment can selectively bind to integrins on the surface of tumor cells and are attractive transport molecules for the targeted delivery of therapeutic and diagnostic agents to tumors (for example, glioblastoma). We have demonstrated the possibility o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3467 |
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| author | Alexander V. Vakhrushev Dmitry A. Gruzdev Alexander M. Demin Galina L. Levit Victor P. Krasnov |
| author_facet | Alexander V. Vakhrushev Dmitry A. Gruzdev Alexander M. Demin Galina L. Levit Victor P. Krasnov |
| author_sort | Alexander V. Vakhrushev |
| collection | DOAJ |
| description | Short peptides containing the Arg-Gly-Asp (RGD) fragment can selectively bind to integrins on the surface of tumor cells and are attractive transport molecules for the targeted delivery of therapeutic and diagnostic agents to tumors (for example, glioblastoma). We have demonstrated the possibility of obtaining the <i>N</i>- and <i>C</i>-protected RGD peptide containing 3-amino-<i>closo</i>-carborane and a glutaric acid residue as a linker fragment. The resulting carboranyl derivatives of the protected RGD peptide are of interest as starting compounds in the synthesis of unprotected or selectively protected peptides, as well as building blocks for preparation of boron-containing derivatives of the RGD peptide of a more complex structure. |
| first_indexed | 2024-03-11T04:41:15Z |
| format | Article |
| id | doaj.art-2f820cd5453849298293db8cfdbd5db1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:41:15Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2f820cd5453849298293db8cfdbd5db12023-11-17T20:39:23ZengMDPI AGMolecules1420-30492023-04-01288346710.3390/molecules28083467Synthesis of Novel Carborane-Containing Derivatives of RGD PeptideAlexander V. Vakhrushev0Dmitry A. Gruzdev1Alexander M. Demin2Galina L. Levit3Victor P. Krasnov4Postovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), 620108 Ekaterinburg, RussiaPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), 620108 Ekaterinburg, RussiaPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), 620108 Ekaterinburg, RussiaPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), 620108 Ekaterinburg, RussiaPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), 620108 Ekaterinburg, RussiaShort peptides containing the Arg-Gly-Asp (RGD) fragment can selectively bind to integrins on the surface of tumor cells and are attractive transport molecules for the targeted delivery of therapeutic and diagnostic agents to tumors (for example, glioblastoma). We have demonstrated the possibility of obtaining the <i>N</i>- and <i>C</i>-protected RGD peptide containing 3-amino-<i>closo</i>-carborane and a glutaric acid residue as a linker fragment. The resulting carboranyl derivatives of the protected RGD peptide are of interest as starting compounds in the synthesis of unprotected or selectively protected peptides, as well as building blocks for preparation of boron-containing derivatives of the RGD peptide of a more complex structure.https://www.mdpi.com/1420-3049/28/8/34673-amino-1,2-dicarba-<i>closo</i>-dodecaboraneRGD peptidelinker fragmentprotecting groups |
| spellingShingle | Alexander V. Vakhrushev Dmitry A. Gruzdev Alexander M. Demin Galina L. Levit Victor P. Krasnov Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide Molecules 3-amino-1,2-dicarba-<i>closo</i>-dodecaborane RGD peptide linker fragment protecting groups |
| title | Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide |
| title_full | Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide |
| title_fullStr | Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide |
| title_full_unstemmed | Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide |
| title_short | Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide |
| title_sort | synthesis of novel carborane containing derivatives of rgd peptide |
| topic | 3-amino-1,2-dicarba-<i>closo</i>-dodecaborane RGD peptide linker fragment protecting groups |
| url | https://www.mdpi.com/1420-3049/28/8/3467 |
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