The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation Therapy
Many patients with non-metastatic breast cancer benefit from adjuvant radiation therapy after lumpectomy or mastectomy on the basis of many randomized trials. However, there are many patients that have such low risks of recurrence after surgery that de-intensification of therapy by either reducing t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/98 |
| _version_ | 1797445658655850496 |
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| author | Sasha J. Beyer Miranda Tallman Sachin R. Jhawar Julia R. White Jose G. Bazan |
| author_facet | Sasha J. Beyer Miranda Tallman Sachin R. Jhawar Julia R. White Jose G. Bazan |
| author_sort | Sasha J. Beyer |
| collection | DOAJ |
| description | Many patients with non-metastatic breast cancer benefit from adjuvant radiation therapy after lumpectomy or mastectomy on the basis of many randomized trials. However, there are many patients that have such low risks of recurrence after surgery that de-intensification of therapy by either reducing the treatment volume or omitting radiation altogether may be appropriate options. On the other hand, dose intensification may be necessary for more aggressive breast cancers. Until recently, these treatment decisions were based solely on clinicopathologic factors. Here, we review the current literature on the role of genomic assays as prognostic and/or predictive biomarkers to help guide adjuvant radiation therapy decision-making. |
| first_indexed | 2024-03-09T13:30:00Z |
| format | Article |
| id | doaj.art-2f82c9ac32ca4681abe857f727b1befe |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:00Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-2f82c9ac32ca4681abe857f727b1befe2023-11-30T21:19:25ZengMDPI AGBiomedicines2227-90592022-12-011119810.3390/biomedicines11010098The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation TherapySasha J. Beyer0Miranda Tallman1Sachin R. Jhawar2Julia R. White3Jose G. Bazan4Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Radiation Oncology, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Radiation Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USAMany patients with non-metastatic breast cancer benefit from adjuvant radiation therapy after lumpectomy or mastectomy on the basis of many randomized trials. However, there are many patients that have such low risks of recurrence after surgery that de-intensification of therapy by either reducing the treatment volume or omitting radiation altogether may be appropriate options. On the other hand, dose intensification may be necessary for more aggressive breast cancers. Until recently, these treatment decisions were based solely on clinicopathologic factors. Here, we review the current literature on the role of genomic assays as prognostic and/or predictive biomarkers to help guide adjuvant radiation therapy decision-making.https://www.mdpi.com/2227-9059/11/1/98breast cancerradiation therapygenomic assays |
| spellingShingle | Sasha J. Beyer Miranda Tallman Sachin R. Jhawar Julia R. White Jose G. Bazan The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation Therapy Biomedicines breast cancer radiation therapy genomic assays |
| title | The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation Therapy |
| title_full | The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation Therapy |
| title_fullStr | The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation Therapy |
| title_full_unstemmed | The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation Therapy |
| title_short | The Prognostic and Predictive Value of Genomic Assays in Guiding Adjuvant Breast Radiation Therapy |
| title_sort | prognostic and predictive value of genomic assays in guiding adjuvant breast radiation therapy |
| topic | breast cancer radiation therapy genomic assays |
| url | https://www.mdpi.com/2227-9059/11/1/98 |
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