Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A Review
Cranial autonomic symptoms (CAS) have been usually associated with trigeminal autonomic cephalalgias (TAC’s), however in the last few years several reports in adult and pediatric population have reported important presence of the CAS in migraine. Also several evidences experimentally show that the i...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-10-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/21/6/10.31083/j.jin2106166 |
| _version_ | 1811304946038996992 |
|---|---|
| author | Salvatore Lo Cascio Edvige Correnti Sofia D’Agostino Mariarita Capizzi Antonio Marino Raffaele Meli Salvatore Lo Nobile Vincenzo Raieli |
| author_facet | Salvatore Lo Cascio Edvige Correnti Sofia D’Agostino Mariarita Capizzi Antonio Marino Raffaele Meli Salvatore Lo Nobile Vincenzo Raieli |
| author_sort | Salvatore Lo Cascio |
| collection | DOAJ |
| description | Cranial autonomic symptoms (CAS) have been usually associated with trigeminal autonomic cephalalgias (TAC’s), however in the last few years several reports in adult and pediatric population have reported important presence of the CAS in migraine. Also several evidences experimentally show that the increased parasympathetic outflow can enhance the sensitization of nociceptive receptors involved in migraine. The presence of CAS suggests an activation of the trigeminal-autonomic reflex, probably related to an over-activation of the trigeminal afferent arm. For these reasons identifing and understanding of these symptoms in migraine may be important to help in the diagnosis and effective management. The purpose of this review is, analyzing the literature data, to discuss the prevalence of these CAS in migraine, the pathophysiological meaning in the pathogenesis of migraine and whether their presence influences the prognosis and therapy of migraine in adult and pediatric age. |
| first_indexed | 2024-04-13T08:16:37Z |
| format | Article |
| id | doaj.art-2f85d7d166544487bbc664e8ea272e47 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-04-13T08:16:37Z |
| publishDate | 2022-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-2f85d7d166544487bbc664e8ea272e472022-12-22T02:54:46ZengIMR PressJournal of Integrative Neuroscience0219-63522022-10-0121616610.31083/j.jin2106166S0219-6352(22)00428-4Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A ReviewSalvatore Lo Cascio0Edvige Correnti1Sofia D’Agostino2Mariarita Capizzi3Antonio Marino4Raffaele Meli5Salvatore Lo Nobile6Vincenzo Raieli7Child Neuropsychiatry Unit Department, Pro.M.I.S.E. "G D'Alessandro", University of Palermo, 90133 Palermo, ItalyChild Neuropsychiatry Department, ISMEP - ARNAS Civico Palermo, via dei Benedettini, 90100 Palermo, ItalyChild Neuropsychiatry Unit Department, Pro.M.I.S.E. "G D'Alessandro", University of Palermo, 90133 Palermo, ItalyChild Neuropsychiatry Unit Department, Pro.M.I.S.E. "G D'Alessandro", University of Palermo, 90133 Palermo, ItalyChild Neuropsychiatry Unit Department, Pro.M.I.S.E. "G D'Alessandro", University of Palermo, 90133 Palermo, ItalyChild Neuropsychiatry Unit Department, Pro.M.I.S.E. "G D'Alessandro", University of Palermo, 90133 Palermo, ItalyChild Neuropsychiatry Unit Department, Pro.M.I.S.E. "G D'Alessandro", University of Palermo, 90133 Palermo, ItalyChild Neuropsychiatry Department, ISMEP - ARNAS Civico Palermo, via dei Benedettini, 90100 Palermo, ItalyCranial autonomic symptoms (CAS) have been usually associated with trigeminal autonomic cephalalgias (TAC’s), however in the last few years several reports in adult and pediatric population have reported important presence of the CAS in migraine. Also several evidences experimentally show that the increased parasympathetic outflow can enhance the sensitization of nociceptive receptors involved in migraine. The presence of CAS suggests an activation of the trigeminal-autonomic reflex, probably related to an over-activation of the trigeminal afferent arm. For these reasons identifing and understanding of these symptoms in migraine may be important to help in the diagnosis and effective management. The purpose of this review is, analyzing the literature data, to discuss the prevalence of these CAS in migraine, the pathophysiological meaning in the pathogenesis of migraine and whether their presence influences the prognosis and therapy of migraine in adult and pediatric age.https://www.imrpress.com/journal/JIN/21/6/10.31083/j.jin2106166migrainecranial autonomic symptomsparasympathetic systemchildrenadulttrigeminal autonomic cephalgias |
| spellingShingle | Salvatore Lo Cascio Edvige Correnti Sofia D’Agostino Mariarita Capizzi Antonio Marino Raffaele Meli Salvatore Lo Nobile Vincenzo Raieli Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A Review Journal of Integrative Neuroscience migraine cranial autonomic symptoms parasympathetic system children adult trigeminal autonomic cephalgias |
| title | Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A Review |
| title_full | Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A Review |
| title_fullStr | Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A Review |
| title_full_unstemmed | Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A Review |
| title_short | Cranial Autonomic Symptoms and Migraine: What Relationship and What Meaning? A Review |
| title_sort | cranial autonomic symptoms and migraine what relationship and what meaning a review |
| topic | migraine cranial autonomic symptoms parasympathetic system children adult trigeminal autonomic cephalgias |
| url | https://www.imrpress.com/journal/JIN/21/6/10.31083/j.jin2106166 |
| work_keys_str_mv | AT salvatorelocascio cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview AT edvigecorrenti cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview AT sofiadagostino cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview AT mariaritacapizzi cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview AT antoniomarino cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview AT raffaelemeli cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview AT salvatorelonobile cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview AT vincenzoraieli cranialautonomicsymptomsandmigrainewhatrelationshipandwhatmeaningareview |