Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release
Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/13/3/282 |
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| author | Florentina Mihaela Păncescu Abbas Abdul Kadhim Klaif Rikabi Ovidiu Cristian Oprea Alexandra Raluca Grosu Aurelia Cristina Nechifor Vlad-Alexandru Grosu Szidonia-Katalin Tanczos Florina Dumitru Gheorghe Nechifor Simona Gabriela Bungău |
| author_facet | Florentina Mihaela Păncescu Abbas Abdul Kadhim Klaif Rikabi Ovidiu Cristian Oprea Alexandra Raluca Grosu Aurelia Cristina Nechifor Vlad-Alexandru Grosu Szidonia-Katalin Tanczos Florina Dumitru Gheorghe Nechifor Simona Gabriela Bungău |
| author_sort | Florentina Mihaela Păncescu |
| collection | DOAJ |
| description | Melatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene (<i>w/w</i>), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, <i>w/w</i>). For the comparative evaluation of the membranes’ performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, <i>w/w/w</i>) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm<sup>2</sup>·per day (sEPDM), 1.6 mg/ cm<sup>2</sup>·per day (Chi/sEPDM), and 1.25 mg/cm<sup>2</sup>·per day (Mel/Chi/SEPDM). |
| first_indexed | 2024-03-11T06:12:07Z |
| format | Article |
| id | doaj.art-2f869ccedaed42d083c8ae4da5782ec5 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-11T06:12:07Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-2f869ccedaed42d083c8ae4da5782ec52023-11-17T12:34:24ZengMDPI AGMembranes2077-03752023-02-0113328210.3390/membranes13030282Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and ReleaseFlorentina Mihaela Păncescu0Abbas Abdul Kadhim Klaif Rikabi1Ovidiu Cristian Oprea2Alexandra Raluca Grosu3Aurelia Cristina Nechifor4Vlad-Alexandru Grosu5Szidonia-Katalin Tanczos6Florina Dumitru7Gheorghe Nechifor8Simona Gabriela Bungău9Analytical Chemistry and Environmental Engineering Department, University Politehnica of Bucharest, 011061 Bucharest, RomaniaAnalytical Chemistry and Environmental Engineering Department, University Politehnica of Bucharest, 011061 Bucharest, RomaniaDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 011061 Bucharest, RomaniaAnalytical Chemistry and Environmental Engineering Department, University Politehnica of Bucharest, 011061 Bucharest, RomaniaAnalytical Chemistry and Environmental Engineering Department, University Politehnica of Bucharest, 011061 Bucharest, RomaniaDepartment of Electronic Technology and Reliability, Faculty of Electronics, Telecommunications and Information Technology, University Politehnica of Bucharest, 061071 Bucharest, RomaniaDepartment of Bioengineering, University Sapientia of Miercurea-Ciuc, 500104 Miercurea-Ciuc, RomaniaDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 011061 Bucharest, RomaniaAnalytical Chemistry and Environmental Engineering Department, University Politehnica of Bucharest, 011061 Bucharest, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaMelatonin is the hormone that focuses the attention of the researchers in the medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety of techniques and methods for the controlled release of melatonin is linked to the multitude of applications, among which sports medicine occupies a special place. This paper presents the preparation and characterization of composite membranes based on chitosan (Chi) and sulfonated ethylene-propylene-diene terpolymer (sEPDM). The membranes were obtained by controlled vacuum evaporation from an 8% sEPDM solution in toluene (<i>w/w</i>), in which chitosan was dispersed in an ultrasonic field (sEPDM:Chi = 1:1, <i>w/w</i>). For the comparative evaluation of the membranes’ performances, a melatonin-chitosan-sulfonated ethylene-propylene-diene terpolymer (Mel:Chi:sEPDM = 0.5:0.5:1.0, <i>w/w/w</i>) test membrane was made. The prepared membranes were morphologically and structurally characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy analysis (EDAX), thermal analysis (TG, DSC), thermal analysis coupled with chromatography and infrared analysis, and contact angle measurements, but also from the point of view of performance in the process of transport and release of melatonin in dedicated environments (aqueous solutions with controlled pH and salinity). The prepared membranes can release melatonin in amounts between 0.4 mg/cm<sup>2</sup>·per day (sEPDM), 1.6 mg/ cm<sup>2</sup>·per day (Chi/sEPDM), and 1.25 mg/cm<sup>2</sup>·per day (Mel/Chi/SEPDM).https://www.mdpi.com/2077-0375/13/3/282melatonincomposite membraneschitosansEPDMmelatonin transport and release |
| spellingShingle | Florentina Mihaela Păncescu Abbas Abdul Kadhim Klaif Rikabi Ovidiu Cristian Oprea Alexandra Raluca Grosu Aurelia Cristina Nechifor Vlad-Alexandru Grosu Szidonia-Katalin Tanczos Florina Dumitru Gheorghe Nechifor Simona Gabriela Bungău Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release Membranes melatonin composite membranes chitosan sEPDM melatonin transport and release |
| title | Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release |
| title_full | Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release |
| title_fullStr | Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release |
| title_full_unstemmed | Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release |
| title_short | Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release |
| title_sort | chitosan sepdm and melatonin chitosan sepdm composite membranes for melatonin transport and release |
| topic | melatonin composite membranes chitosan sEPDM melatonin transport and release |
| url | https://www.mdpi.com/2077-0375/13/3/282 |
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