Synthesis of some New 1,2,4-Triazole derivatives
In the present work, compound 3-arylidene amino-5-methyl-1,2,4-triazole (IIIa-c), required as starting material obtained in one-pot reaction by condensing 5-methyl-3-amino-1,2,4-triazole with different aromatic aldehydes. The required 5-methyl-3-amino-1,2,4-triazole was prepared from treatment of ac...
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| Format: | Article |
| Language: | English |
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University of Anbar
2013-11-01
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| Series: | مجلة جامعة الانبار للعلوم الصرفة |
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| Online Access: | https://juaps.uoanbar.edu.iq/article_83187_32c6419198a21be476ae29f6e0ea121c.pdf |
| _version_ | 1797373257816473600 |
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| author | Ibtehal Kahtan Abdullah |
| author_facet | Ibtehal Kahtan Abdullah |
| author_sort | Ibtehal Kahtan Abdullah |
| collection | DOAJ |
| description | In the present work, compound 3-arylidene amino-5-methyl-1,2,4-triazole (IIIa-c), required as starting material obtained in one-pot reaction by condensing 5-methyl-3-amino-1,2,4-triazole with different aromatic aldehydes. The required 5-methyl-3-amino-1,2,4-triazole was prepared from treatment of acetyl urea (I) with hydrazine hydrate, the compounds (IIIa-c) were converted to the corresponding [3-[5-methyl-1,2,4-triazol-2-yl]-2-arylthiazolidine-4-one (Va1-a3) and imidazoleine-4-one (Vb1-b3) by reacted it with thioglycolic acid and Glycine in absolute ethanol. The compounds (IIa-c) were converted also to 2-methyl-5-arylamino-5,6,-dihydroimidozo[2,1-b]-1,2,4-triazole (VIIIa-VIIIc) reacted with TCA then with aniline derivatives. The linear pathway strategy of all these synthesized compounds can be summarized in scheme (1). |
| first_indexed | 2024-03-08T18:47:48Z |
| format | Article |
| id | doaj.art-2f8affe1e3bb451381668147d053ffdc |
| institution | Directory Open Access Journal |
| issn | 1991-8941 2706-6703 |
| language | English |
| last_indexed | 2024-03-08T18:47:48Z |
| publishDate | 2013-11-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | مجلة جامعة الانبار للعلوم الصرفة |
| spelling | doaj.art-2f8affe1e3bb451381668147d053ffdc2023-12-28T21:56:51ZengUniversity of Anbarمجلة جامعة الانبار للعلوم الصرفة1991-89412706-67032013-11-0171819010.37652/juaps.2013.8318783187Synthesis of some New 1,2,4-Triazole derivativesIbtehal Kahtan Abdullah0University Of Tikrit – College Of Science.In the present work, compound 3-arylidene amino-5-methyl-1,2,4-triazole (IIIa-c), required as starting material obtained in one-pot reaction by condensing 5-methyl-3-amino-1,2,4-triazole with different aromatic aldehydes. The required 5-methyl-3-amino-1,2,4-triazole was prepared from treatment of acetyl urea (I) with hydrazine hydrate, the compounds (IIIa-c) were converted to the corresponding [3-[5-methyl-1,2,4-triazol-2-yl]-2-arylthiazolidine-4-one (Va1-a3) and imidazoleine-4-one (Vb1-b3) by reacted it with thioglycolic acid and Glycine in absolute ethanol. The compounds (IIa-c) were converted also to 2-methyl-5-arylamino-5,6,-dihydroimidozo[2,1-b]-1,2,4-triazole (VIIIa-VIIIc) reacted with TCA then with aniline derivatives. The linear pathway strategy of all these synthesized compounds can be summarized in scheme (1).https://juaps.uoanbar.edu.iq/article_83187_32c6419198a21be476ae29f6e0ea121c.pdfsynthesistriazole derivatives |
| spellingShingle | Ibtehal Kahtan Abdullah Synthesis of some New 1,2,4-Triazole derivatives مجلة جامعة الانبار للعلوم الصرفة synthesis triazole derivatives |
| title | Synthesis of some New 1,2,4-Triazole derivatives |
| title_full | Synthesis of some New 1,2,4-Triazole derivatives |
| title_fullStr | Synthesis of some New 1,2,4-Triazole derivatives |
| title_full_unstemmed | Synthesis of some New 1,2,4-Triazole derivatives |
| title_short | Synthesis of some New 1,2,4-Triazole derivatives |
| title_sort | synthesis of some new 1 2 4 triazole derivatives |
| topic | synthesis triazole derivatives |
| url | https://juaps.uoanbar.edu.iq/article_83187_32c6419198a21be476ae29f6e0ea121c.pdf |
| work_keys_str_mv | AT ibtehalkahtanabdullah synthesisofsomenew124triazolederivatives |