An Overview of Anticancer Chalcones with Apoptosis Inducing Activity
Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could selectively target cancer cells. Thus, designing and...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2017-03-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-9663-en.html |
| _version_ | 1797943630325874688 |
|---|---|
| author | Hassan Mirzaei Masoud Keighobadi Saeed Emami |
| author_facet | Hassan Mirzaei Masoud Keighobadi Saeed Emami |
| author_sort | Hassan Mirzaei |
| collection | DOAJ |
| description | Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could selectively target cancer cells. Thus, designing and discovering new efficient and selective anticancer agents are urgent needs. It is important that new anticancer agents could act via apoptosis induction, since it has a critical role in control of cell proliferation. Chalcones are naturally occurring compounds possessing high degree of synthetic diversity for design of new leading bioactive compounds including anticancer agents. Chalcones are considered as promising anticancer agents against most human cancers with capability of inducing apoptosis in cancer cells. Furthermore, some clinically useful anticancer drugs show genotoxicity due to interaction with DNA, but chalcones with different mechanism may be devoid of this side effect. This review highlights the recently identified anticancer chalcones from naturally or synthetically origins that induce apoptosis in cancer cells. The diversity of scaffolds described in this review along with their structure-activity relationships could help medicinal chemists in development of new selective anticancer chalcones with improved potency. |
| first_indexed | 2024-04-10T20:27:12Z |
| format | Article |
| id | doaj.art-2f8d3eccd0654978a3e73d74d1fcda2a |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:27:12Z |
| publishDate | 2017-03-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-2f8d3eccd0654978a3e73d74d1fcda2a2023-01-25T08:42:32ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792017-03-0126146254268An Overview of Anticancer Chalcones with Apoptosis Inducing ActivityHassan Mirzaei0Masoud Keighobadi1Saeed Emami2 Ph.D Student, Pharmaceutical Sciences Research Center, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Ph.D Student, Pharmaceutical Sciences Research Center, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Professor, Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could selectively target cancer cells. Thus, designing and discovering new efficient and selective anticancer agents are urgent needs. It is important that new anticancer agents could act via apoptosis induction, since it has a critical role in control of cell proliferation. Chalcones are naturally occurring compounds possessing high degree of synthetic diversity for design of new leading bioactive compounds including anticancer agents. Chalcones are considered as promising anticancer agents against most human cancers with capability of inducing apoptosis in cancer cells. Furthermore, some clinically useful anticancer drugs show genotoxicity due to interaction with DNA, but chalcones with different mechanism may be devoid of this side effect. This review highlights the recently identified anticancer chalcones from naturally or synthetically origins that induce apoptosis in cancer cells. The diversity of scaffolds described in this review along with their structure-activity relationships could help medicinal chemists in development of new selective anticancer chalcones with improved potency.http://jmums.mazums.ac.ir/article-1-9663-en.htmlcanceranticancer agentsapoptosischalconesdrug discovery |
| spellingShingle | Hassan Mirzaei Masoud Keighobadi Saeed Emami An Overview of Anticancer Chalcones with Apoptosis Inducing Activity Journal of Mazandaran University of Medical Sciences cancer anticancer agents apoptosis chalcones drug discovery |
| title | An Overview of Anticancer Chalcones with Apoptosis
Inducing Activity |
| title_full | An Overview of Anticancer Chalcones with Apoptosis
Inducing Activity |
| title_fullStr | An Overview of Anticancer Chalcones with Apoptosis
Inducing Activity |
| title_full_unstemmed | An Overview of Anticancer Chalcones with Apoptosis
Inducing Activity |
| title_short | An Overview of Anticancer Chalcones with Apoptosis
Inducing Activity |
| title_sort | overview of anticancer chalcones with apoptosis inducing activity |
| topic | cancer anticancer agents apoptosis chalcones drug discovery |
| url | http://jmums.mazums.ac.ir/article-1-9663-en.html |
| work_keys_str_mv | AT hassanmirzaei anoverviewofanticancerchalconeswithapoptosisinducingactivity AT masoudkeighobadi anoverviewofanticancerchalconeswithapoptosisinducingactivity AT saeedemami anoverviewofanticancerchalconeswithapoptosisinducingactivity AT hassanmirzaei overviewofanticancerchalconeswithapoptosisinducingactivity AT masoudkeighobadi overviewofanticancerchalconeswithapoptosisinducingactivity AT saeedemami overviewofanticancerchalconeswithapoptosisinducingactivity |