Patterns of evolution of host proteins involved in retroviral pathogenesis
<p>Abstract</p> <p>Background</p> <p>Evolutionary analysis may serve as a useful approach to identify and characterize host defense and viral proteins involved in genetic conflicts. We analyzed patterns of coding sequence evolution of genes with known (<it>TRIM5&l...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-02-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/3/1/11 |
| _version_ | 1828234155800920064 |
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| author | Kaessmann Henrik Martinez Raquel Bleiber Gabriela Ortiz Millan Telenti Amalio |
| author_facet | Kaessmann Henrik Martinez Raquel Bleiber Gabriela Ortiz Millan Telenti Amalio |
| author_sort | Kaessmann Henrik |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Evolutionary analysis may serve as a useful approach to identify and characterize host defense and viral proteins involved in genetic conflicts. We analyzed patterns of coding sequence evolution of genes with known (<it>TRIM5</it>α and <it>APOBEC3G</it>) or suspected (<it>TRIM19</it>/<it>PML</it>) roles in virus restriction, or in viral pathogenesis (<it>PPIA</it>, encoding Cyclophilin A), in the same set of human and non-human primate species.</p> <p>Results and conclusion</p> <p>This analysis revealed previously unidentified clusters of positively selected sites in <it>APOBEC3G </it>and <it>TRIM5</it>α that may delineate new virus-interaction domains. In contrast, our evolutionary analyses suggest that <it>PPIA </it>is not under diversifying selection in primates, consistent with the interaction of Cyclophilin A being limited to the HIV-1M/SIVcpz lineage. The strong sequence conservation of the <it>TRIM19/PML </it>sequences among primates suggests that this gene does not play a role in antiretroviral defense.</p> |
| first_indexed | 2024-04-12T19:50:45Z |
| format | Article |
| id | doaj.art-2f8dd72e37444d03a5868adf0a480c65 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-04-12T19:50:45Z |
| publishDate | 2006-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-2f8dd72e37444d03a5868adf0a480c652022-12-22T03:18:50ZengBMCRetrovirology1742-46902006-02-01311110.1186/1742-4690-3-11Patterns of evolution of host proteins involved in retroviral pathogenesisKaessmann HenrikMartinez RaquelBleiber GabrielaOrtiz MillanTelenti Amalio<p>Abstract</p> <p>Background</p> <p>Evolutionary analysis may serve as a useful approach to identify and characterize host defense and viral proteins involved in genetic conflicts. We analyzed patterns of coding sequence evolution of genes with known (<it>TRIM5</it>α and <it>APOBEC3G</it>) or suspected (<it>TRIM19</it>/<it>PML</it>) roles in virus restriction, or in viral pathogenesis (<it>PPIA</it>, encoding Cyclophilin A), in the same set of human and non-human primate species.</p> <p>Results and conclusion</p> <p>This analysis revealed previously unidentified clusters of positively selected sites in <it>APOBEC3G </it>and <it>TRIM5</it>α that may delineate new virus-interaction domains. In contrast, our evolutionary analyses suggest that <it>PPIA </it>is not under diversifying selection in primates, consistent with the interaction of Cyclophilin A being limited to the HIV-1M/SIVcpz lineage. The strong sequence conservation of the <it>TRIM19/PML </it>sequences among primates suggests that this gene does not play a role in antiretroviral defense.</p>http://www.retrovirology.com/content/3/1/11 |
| spellingShingle | Kaessmann Henrik Martinez Raquel Bleiber Gabriela Ortiz Millan Telenti Amalio Patterns of evolution of host proteins involved in retroviral pathogenesis Retrovirology |
| title | Patterns of evolution of host proteins involved in retroviral pathogenesis |
| title_full | Patterns of evolution of host proteins involved in retroviral pathogenesis |
| title_fullStr | Patterns of evolution of host proteins involved in retroviral pathogenesis |
| title_full_unstemmed | Patterns of evolution of host proteins involved in retroviral pathogenesis |
| title_short | Patterns of evolution of host proteins involved in retroviral pathogenesis |
| title_sort | patterns of evolution of host proteins involved in retroviral pathogenesis |
| url | http://www.retrovirology.com/content/3/1/11 |
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