Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion system
According to global health statistics, respiratory diseases, together with infectious complications and hereditary lung diseases, rank as the third leading cause of death. Today, lung transplantation (LTx) is a well-recognized modality of treatment for end-stage chronic lung disease. However, the nu...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2022-07-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/1445 |
| _version_ | 1797871916520833024 |
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| author | S. V. Gautier O. M. Tsirulnikova I. V. Pashkov D. O. Oleshkevich I. A. Filatov V. K. Bogdanov D. M. Bondarenko N. P. Mozheiko A. A. Karpov N. S. Bunenkov N. V. Grudinin |
| author_facet | S. V. Gautier O. M. Tsirulnikova I. V. Pashkov D. O. Oleshkevich I. A. Filatov V. K. Bogdanov D. M. Bondarenko N. P. Mozheiko A. A. Karpov N. S. Bunenkov N. V. Grudinin |
| author_sort | S. V. Gautier |
| collection | DOAJ |
| description | According to global health statistics, respiratory diseases, together with infectious complications and hereditary lung diseases, rank as the third leading cause of death. Today, lung transplantation (LTx) is a well-recognized modality of treatment for end-stage chronic lung disease. However, the number of LTx surgeries performed is much lower than other solid organs. This is due to the high requirements for the potential donor and characteristics of the lung graft, reflecting the efficiency of gas exchange function. Non-compliance with the selection criteria leads to deselection of donors, which, according to various estimates, occurs in 80–85% of cases. One of the ways to increase the number of lung transplant surgeries is to restore them to the level of optimal gas exchange parameters, which can be achieved and objectively assessed during normothermic ex vivo lung perfusion (EVLP). EVLP is becoming increasingly common at leading transplantation centers in Europe and North America. This has significantly increased the number of transplant surgeries as a result of using lungs procured from suboptimal donors and rehabilitated via EVLP. In our pilot study, the developed Russian-made mechanical circulatory support system showed that performing normothermic EVLP for isolated lungs under experimental conditions is feasible. Basic and optimized perfusion protocols have fully shown that they are reliable and efficient. |
| first_indexed | 2024-04-10T00:50:31Z |
| format | Article |
| id | doaj.art-2f8e6912938c41c094f08e9ceaa3de48 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:50:31Z |
| publishDate | 2022-07-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-2f8e6912938c41c094f08e9ceaa3de482023-03-13T10:37:28ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912022-07-012429410110.15825/1995-1191-2022-2-94-1011104Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion systemS. V. Gautier0O. M. Tsirulnikova1I. V. Pashkov2D. O. Oleshkevich3I. A. Filatov4V. K. Bogdanov5D. M. Bondarenko6N. P. Mozheiko7A. A. Karpov8N. S. Bunenkov9N. V. Grudinin10Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansBiosoft-MBiosoft-MShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansAlmazov National Medical Research CentreAlmazov National Medical Research Centre; Pavlov UniversityShumakov National Medical Research Center of Transplantology and Artificial OrgansAccording to global health statistics, respiratory diseases, together with infectious complications and hereditary lung diseases, rank as the third leading cause of death. Today, lung transplantation (LTx) is a well-recognized modality of treatment for end-stage chronic lung disease. However, the number of LTx surgeries performed is much lower than other solid organs. This is due to the high requirements for the potential donor and characteristics of the lung graft, reflecting the efficiency of gas exchange function. Non-compliance with the selection criteria leads to deselection of donors, which, according to various estimates, occurs in 80–85% of cases. One of the ways to increase the number of lung transplant surgeries is to restore them to the level of optimal gas exchange parameters, which can be achieved and objectively assessed during normothermic ex vivo lung perfusion (EVLP). EVLP is becoming increasingly common at leading transplantation centers in Europe and North America. This has significantly increased the number of transplant surgeries as a result of using lungs procured from suboptimal donors and rehabilitated via EVLP. In our pilot study, the developed Russian-made mechanical circulatory support system showed that performing normothermic EVLP for isolated lungs under experimental conditions is feasible. Basic and optimized perfusion protocols have fully shown that they are reliable and efficient.https://journal.transpl.ru/vtio/article/view/1445lung transplantationdonationex-vivo perfusion |
| spellingShingle | S. V. Gautier O. M. Tsirulnikova I. V. Pashkov D. O. Oleshkevich I. A. Filatov V. K. Bogdanov D. M. Bondarenko N. P. Mozheiko A. A. Karpov N. S. Bunenkov N. V. Grudinin Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion system Vestnik Transplantologii i Iskusstvennyh Organov lung transplantation donation ex-vivo perfusion |
| title | Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion system |
| title_full | Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion system |
| title_fullStr | Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion system |
| title_full_unstemmed | Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion system |
| title_short | Normothermic <i>ex vivo</i> perfusion of isolated lungs in an experiment using a russian-made perfusion system |
| title_sort | normothermic i ex vivo i perfusion of isolated lungs in an experiment using a russian made perfusion system |
| topic | lung transplantation donation ex-vivo perfusion |
| url | https://journal.transpl.ru/vtio/article/view/1445 |
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