RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Abstract Background TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Furthermore, its RNA-binding...

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Bibliographic Details
Main Authors: Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Biology
Subjects:
Novel RNA-binding proteins
TRIM25
ZAP
RNA-binding domain
PRY/SPRY
Online Access:http://link.springer.com/article/10.1186/s12915-017-0444-9

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