Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review
Non-cystic fibrosis bronchiectasis is a chronic disorder in which immune system dysregulation and impaired airway clearance cause mucus accumulation and consequent increased susceptibility to lung infections. The presence of pathogens in the lower respiratory tract causes a vicious circle resulting...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/3/326 |
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| author | Riccardo Inchingolo Chiara Pierandrei Giuliano Montemurro Andrea Smargiassi Franziska Michaela Lohmeyer Angela Rizzi |
| author_facet | Riccardo Inchingolo Chiara Pierandrei Giuliano Montemurro Andrea Smargiassi Franziska Michaela Lohmeyer Angela Rizzi |
| author_sort | Riccardo Inchingolo |
| collection | DOAJ |
| description | Non-cystic fibrosis bronchiectasis is a chronic disorder in which immune system dysregulation and impaired airway clearance cause mucus accumulation and consequent increased susceptibility to lung infections. The presence of pathogens in the lower respiratory tract causes a vicious circle resulting in impaired mucociliary function, bronchial inflammation, and progressive lung injury. In current guidelines, antibiotic therapy has a key role in bronchiectasis management to treat acute exacerbations and chronic infection and to eradicate bacterial colonization. Contrastingly, antimicrobial resistance, with the risk of multidrug-resistant pathogen development, causes nowadays great concern. The aim of this literature review was to assess the role of antibiotic therapy in bronchiectasis patient management and possible concerns regarding antimicrobial resistance based on current evidence. The authors of this review stress the need to expand research regarding bronchiectasis with the aim to assess measures to reduce the rate of antimicrobial resistance worldwide. |
| first_indexed | 2024-03-10T13:03:39Z |
| format | Article |
| id | doaj.art-2f8ea5c9461f4c4fb8a639538f0ea5fb |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T13:03:39Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-2f8ea5c9461f4c4fb8a639538f0ea5fb2023-11-21T11:17:13ZengMDPI AGAntibiotics2079-63822021-03-0110332610.3390/antibiotics10030326Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature ReviewRiccardo Inchingolo0Chiara Pierandrei1Giuliano Montemurro2Andrea Smargiassi3Franziska Michaela Lohmeyer4Angela Rizzi5UOC Pneumologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyUOC Pneumologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyUOC Pneumologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyUOC Pneumologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDirezione Scientifica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyUOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNon-cystic fibrosis bronchiectasis is a chronic disorder in which immune system dysregulation and impaired airway clearance cause mucus accumulation and consequent increased susceptibility to lung infections. The presence of pathogens in the lower respiratory tract causes a vicious circle resulting in impaired mucociliary function, bronchial inflammation, and progressive lung injury. In current guidelines, antibiotic therapy has a key role in bronchiectasis management to treat acute exacerbations and chronic infection and to eradicate bacterial colonization. Contrastingly, antimicrobial resistance, with the risk of multidrug-resistant pathogen development, causes nowadays great concern. The aim of this literature review was to assess the role of antibiotic therapy in bronchiectasis patient management and possible concerns regarding antimicrobial resistance based on current evidence. The authors of this review stress the need to expand research regarding bronchiectasis with the aim to assess measures to reduce the rate of antimicrobial resistance worldwide.https://www.mdpi.com/2079-6382/10/3/326non-cystic fibrosis bronchiectasismultidrug-resistant (MDR) pathogens<i>Pseudomonas aeuriginosa</i>antimicrobial resistance (AMR)inhaled antibioticmacrolides |
| spellingShingle | Riccardo Inchingolo Chiara Pierandrei Giuliano Montemurro Andrea Smargiassi Franziska Michaela Lohmeyer Angela Rizzi Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review Antibiotics non-cystic fibrosis bronchiectasis multidrug-resistant (MDR) pathogens <i>Pseudomonas aeuriginosa</i> antimicrobial resistance (AMR) inhaled antibiotic macrolides |
| title | Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review |
| title_full | Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review |
| title_fullStr | Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review |
| title_full_unstemmed | Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review |
| title_short | Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review |
| title_sort | antimicrobial resistance in common respiratory pathogens of chronic bronchiectasis patients a literature review |
| topic | non-cystic fibrosis bronchiectasis multidrug-resistant (MDR) pathogens <i>Pseudomonas aeuriginosa</i> antimicrobial resistance (AMR) inhaled antibiotic macrolides |
| url | https://www.mdpi.com/2079-6382/10/3/326 |
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