Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis
Purpose: The aim of this study was to prepare the optimized oral paste formulation of Triamcinolone acetonide intended to be used in aphtous stomatitis. Methods: Plastibases were prepared using mineral oil and polyethylene (95:5). Oral paste formulations were prepared with different mixtures of t...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2015-06-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Abstract/APB_304_20140816060108 |
| _version_ | 1811247416880398336 |
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| author | Hamed Hamishehkar Ali Nokhodchi Saeed Ghanbarzadeh Maryam Kouhsoltani |
| author_facet | Hamed Hamishehkar Ali Nokhodchi Saeed Ghanbarzadeh Maryam Kouhsoltani |
| author_sort | Hamed Hamishehkar |
| collection | DOAJ |
| description | Purpose: The aim of this study was to prepare the optimized oral paste formulation of
Triamcinolone acetonide intended to be used in aphtous stomatitis.
Methods: Plastibases were prepared using mineral oil and polyethylene (95:5). Oral paste
formulations were prepared with different mixtures of three hydrocolloids solids, including
gelatin, pectin and sodium carboxymethylcellulose, with different ratios, as well as
Plastibase. Long-term and short-term stability of prepared formulations were studied in the
case of color and consistency of pastes. Franz diffusion cell and dialysis membrane were
employed for release study. Release data were fitted in the kinetic models to find out the
mechanism of drug release.
Results: Formulation containing 60% plastibase, 3.3% pectin, 6.6% gelatin and 30%
carboxymethylcellulose showed desired durability of adhesion, spreadability and rheology
property in healthy volunteers and was compared with reference formulation (Adcortyl®) in
the case of release profile. Although, optimized formulation and Adcortyl followed the
Higuchi and first order release kinetics respectively, optimized formulation showed similar
release profile to reference formulation.
Conclusion: Optimized oral paste formulation of Triamcinolone Acetonide showed similar
characteristics with reference formulation and could be used as an effective drug delivery
system for the treatment of recurrent aphthous stomatitis. |
| first_indexed | 2024-04-12T15:09:41Z |
| format | Article |
| id | doaj.art-2f8ebb3844dc4d899e8d8f94048de38d |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-04-12T15:09:41Z |
| publishDate | 2015-06-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-2f8ebb3844dc4d899e8d8f94048de38d2022-12-22T03:27:49ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082015-06-015227728210.15171/apb.2015.038Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous StomatitisHamed Hamishehkar0Ali Nokhodchi1Saeed Ghanbarzadeh2Maryam Kouhsoltani3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Medway School of Pharmacy, Universities of Kent and Greenwich, Central Ave., Chatham Maritime, Kent ME4 4TB, United Kingdom.Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Dental and Periodontal Research Center and Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.Purpose: The aim of this study was to prepare the optimized oral paste formulation of Triamcinolone acetonide intended to be used in aphtous stomatitis. Methods: Plastibases were prepared using mineral oil and polyethylene (95:5). Oral paste formulations were prepared with different mixtures of three hydrocolloids solids, including gelatin, pectin and sodium carboxymethylcellulose, with different ratios, as well as Plastibase. Long-term and short-term stability of prepared formulations were studied in the case of color and consistency of pastes. Franz diffusion cell and dialysis membrane were employed for release study. Release data were fitted in the kinetic models to find out the mechanism of drug release. Results: Formulation containing 60% plastibase, 3.3% pectin, 6.6% gelatin and 30% carboxymethylcellulose showed desired durability of adhesion, spreadability and rheology property in healthy volunteers and was compared with reference formulation (Adcortyl®) in the case of release profile. Although, optimized formulation and Adcortyl followed the Higuchi and first order release kinetics respectively, optimized formulation showed similar release profile to reference formulation. Conclusion: Optimized oral paste formulation of Triamcinolone Acetonide showed similar characteristics with reference formulation and could be used as an effective drug delivery system for the treatment of recurrent aphthous stomatitis.http://journals.tbzmed.ac.ir/APB/Abstract/APB_304_20140816060108Aphthous stomatitisTriamcinolone acetonidePlastibaseOral paste |
| spellingShingle | Hamed Hamishehkar Ali Nokhodchi Saeed Ghanbarzadeh Maryam Kouhsoltani Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis Advanced Pharmaceutical Bulletin Aphthous stomatitis Triamcinolone acetonide Plastibase Oral paste |
| title | Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis |
| title_full | Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis |
| title_fullStr | Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis |
| title_full_unstemmed | Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis |
| title_short | Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis |
| title_sort | triamcinolone acetonide oromucoadhesive paste for treatment of aphthous stomatitis |
| topic | Aphthous stomatitis Triamcinolone acetonide Plastibase Oral paste |
| url | http://journals.tbzmed.ac.ir/APB/Abstract/APB_304_20140816060108 |
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