Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection
Objectives: The genetic risk factors that contribute to the risk of developing aortic dissection (AD) have been studied. We assessed the association of endothelial nitric oxide synthase (eNOS) gene polymorphism with AD. Study design: Patients who underwent surgery with the diagnosis of AD and surv...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2014-02-01
|
| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-88269 |
| _version_ | 1797909315293544448 |
|---|---|
| author | Ahmet Ekmekçi Mahmut Uluganyan Barış Güngör Neslihan Abacı Kazım Serhan Özcan Gokhan Ertaş Aycan Zencirci Ahmet Yavuz Balcı Sema Sırma Ekmekçi Nurten Sayar Duran Ustek Mehmet Eren |
| author_facet | Ahmet Ekmekçi Mahmut Uluganyan Barış Güngör Neslihan Abacı Kazım Serhan Özcan Gokhan Ertaş Aycan Zencirci Ahmet Yavuz Balcı Sema Sırma Ekmekçi Nurten Sayar Duran Ustek Mehmet Eren |
| author_sort | Ahmet Ekmekçi |
| collection | DOAJ |
| description | Objectives: The genetic risk factors that contribute to the risk of developing aortic dissection (AD) have been studied. We assessed the association of endothelial nitric oxide synthase (eNOS) gene polymorphism with AD.
Study design: Patients who underwent surgery with the diagnosis of AD and survived after the operation in our center between May 2007 and June 2011 were recruited retrospectively. The eNOS intron 4a/b polymorphism was determined by polymerase chain reaction (PCR) using oligonucleotide primers (sense: 5'-AGGCCCTATGGTAGTGCCTTT-3'; antisense: 5'-TCTCTTAGTGCTGTGGTCAC-3') that flank the region of the 27 bp VNTR in intron 4.
Results: Thirty-nine patients (88%) had type A AD, while the remainder (12%) had type B AD. The distribution of eNOS4 a/b gene polymorphism differed significantly from the control group, with higher frequencies of eNOS 4a/a and 4a/b genotypes in the AD group (χ2=7.16, p=0.03).
Conclusion: In this study, the distribution of eNOS genotypes differed between the AD and control groups; however, this polymorphism was not found to be an independent factor for the development of AD. |
| first_indexed | 2024-04-10T11:06:21Z |
| format | Article |
| id | doaj.art-2f8ffa623aac46558c8d3d7e6f14351b |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T11:06:21Z |
| publishDate | 2014-02-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-2f8ffa623aac46558c8d3d7e6f14351b2023-02-15T16:19:22ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692014-02-01421556010.5543/tkda.2014.88269TKDA-88269Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissectionAhmet Ekmekçi0Mahmut Uluganyan1Barış Güngör2Neslihan Abacı3Kazım Serhan Özcan4Gokhan Ertaş5Aycan Zencirci6Ahmet Yavuz Balcı7Sema Sırma Ekmekçi8Nurten Sayar9Duran Ustek10Mehmet Eren11Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, IstanbulDepartment of Cardiology, Kadirli State Hospital, OsmaniyeDepartment of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, IstanbulDepartment of Genetics, Istanbul University, Institute for Experimental Medical Research, IstanbulDepartment of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, IstanbulDepartment of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, IstanbulDepartment of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, IstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Genetics, Istanbul University, Institute for Experimental Medical Research, IstanbulDepartment of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, IstanbulDepartment of Genetics, Istanbul University, Institute for Experimental Medical Research, IstanbulDepartment of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, IstanbulObjectives: The genetic risk factors that contribute to the risk of developing aortic dissection (AD) have been studied. We assessed the association of endothelial nitric oxide synthase (eNOS) gene polymorphism with AD. Study design: Patients who underwent surgery with the diagnosis of AD and survived after the operation in our center between May 2007 and June 2011 were recruited retrospectively. The eNOS intron 4a/b polymorphism was determined by polymerase chain reaction (PCR) using oligonucleotide primers (sense: 5'-AGGCCCTATGGTAGTGCCTTT-3'; antisense: 5'-TCTCTTAGTGCTGTGGTCAC-3') that flank the region of the 27 bp VNTR in intron 4. Results: Thirty-nine patients (88%) had type A AD, while the remainder (12%) had type B AD. The distribution of eNOS4 a/b gene polymorphism differed significantly from the control group, with higher frequencies of eNOS 4a/a and 4a/b genotypes in the AD group (χ2=7.16, p=0.03). Conclusion: In this study, the distribution of eNOS genotypes differed between the AD and control groups; however, this polymorphism was not found to be an independent factor for the development of AD.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-88269aortic dissectionenos enzymegenetic predisposition to disease; genotype; introns/genetics; nitric oxide; polymorphismgenetic. |
| spellingShingle | Ahmet Ekmekçi Mahmut Uluganyan Barış Güngör Neslihan Abacı Kazım Serhan Özcan Gokhan Ertaş Aycan Zencirci Ahmet Yavuz Balcı Sema Sırma Ekmekçi Nurten Sayar Duran Ustek Mehmet Eren Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection Türk Kardiyoloji Derneği Arşivi aortic dissection enos enzyme genetic predisposition to disease; genotype; introns/genetics; nitric oxide; polymorphism genetic. |
| title | Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection |
| title_full | Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection |
| title_fullStr | Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection |
| title_full_unstemmed | Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection |
| title_short | Association between endothelial nitric oxide synthase intron 4a/b polymorphism and aortic dissection |
| title_sort | association between endothelial nitric oxide synthase intron 4a b polymorphism and aortic dissection |
| topic | aortic dissection enos enzyme genetic predisposition to disease; genotype; introns/genetics; nitric oxide; polymorphism genetic. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-88269 |
| work_keys_str_mv | AT ahmetekmekci associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT mahmutuluganyan associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT barısgungor associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT neslihanabacı associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT kazımserhanozcan associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT gokhanertas associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT aycanzencirci associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT ahmetyavuzbalcı associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT semasırmaekmekci associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT nurtensayar associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT duranustek associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection AT mehmeteren associationbetweenendothelialnitricoxidesynthaseintron4abpolymorphismandaorticdissection |