Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii
Fast diagnostic results using breath analysis are an anticipated possibility for disease diagnosis or general health screenings. Tests that do not require sending specimens to medical laboratories possess capabilities to speed patient diagnosis and protect both patient and healthcare staff from unne...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/12/3726 |
| _version_ | 1797529619740491776 |
|---|---|
| author | Hunter R. Yamanaka Cynthia Cheung Jireh S. Mendoza Danson J. Oliva Kealina Elzey-Aberilla Katelynn A. Perrault |
| author_facet | Hunter R. Yamanaka Cynthia Cheung Jireh S. Mendoza Danson J. Oliva Kealina Elzey-Aberilla Katelynn A. Perrault |
| author_sort | Hunter R. Yamanaka |
| collection | DOAJ |
| description | Fast diagnostic results using breath analysis are an anticipated possibility for disease diagnosis or general health screenings. Tests that do not require sending specimens to medical laboratories possess capabilities to speed patient diagnosis and protect both patient and healthcare staff from unnecessary prolonged exposure. The objective of this work was to develop testing procedures on an initial healthy subject cohort in Hawaii to act as a range-finding pilot study for characterizing the baseline of exhaled breath prior to further research. Using comprehensive two-dimensional gas chromatography (GC×GC), this study analyzed exhaled breath from a healthy adult population in Hawaii to profile the range of different volatile organic compounds (VOCs) and survey Hawaii-specific differences. The most consistently reported compounds in the breath profile of individuals were acetic acid, dimethoxymethane, benzoic acid methyl ester, and <i>n</i>-hexane. In comparison to other breathprinting studies, the list of compounds discovered was representative of control cohorts. This must be considered when implementing proposed breath diagnostics in new locations with increased interpersonal variation due to diversity. Further studies on larger numbers of subjects over longer periods of time will provide additional foundational data on baseline breath VOC profiles of control populations for comparison to disease-positive cohorts. |
| first_indexed | 2024-03-10T10:17:21Z |
| format | Article |
| id | doaj.art-2f90fc5409754d26a27a03b81c138a61 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:17:21Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2f90fc5409754d26a27a03b81c138a612023-11-22T00:42:32ZengMDPI AGMolecules1420-30492021-06-012612372610.3390/molecules26123726Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in HawaiiHunter R. Yamanaka0Cynthia Cheung1Jireh S. Mendoza2Danson J. Oliva3Kealina Elzey-Aberilla4Katelynn A. Perrault5Laboratory of Forensic and Bioanalytical Chemistry, Forensic Sciences Unit, Chaminade University of Honolulu, Honolulu, HI 96816, USALaboratory of Forensic and Bioanalytical Chemistry, Forensic Sciences Unit, Chaminade University of Honolulu, Honolulu, HI 96816, USALaboratory of Forensic and Bioanalytical Chemistry, Forensic Sciences Unit, Chaminade University of Honolulu, Honolulu, HI 96816, USALaboratory of Forensic and Bioanalytical Chemistry, Forensic Sciences Unit, Chaminade University of Honolulu, Honolulu, HI 96816, USALaboratory of Forensic and Bioanalytical Chemistry, Forensic Sciences Unit, Chaminade University of Honolulu, Honolulu, HI 96816, USALaboratory of Forensic and Bioanalytical Chemistry, Forensic Sciences Unit, Chaminade University of Honolulu, Honolulu, HI 96816, USAFast diagnostic results using breath analysis are an anticipated possibility for disease diagnosis or general health screenings. Tests that do not require sending specimens to medical laboratories possess capabilities to speed patient diagnosis and protect both patient and healthcare staff from unnecessary prolonged exposure. The objective of this work was to develop testing procedures on an initial healthy subject cohort in Hawaii to act as a range-finding pilot study for characterizing the baseline of exhaled breath prior to further research. Using comprehensive two-dimensional gas chromatography (GC×GC), this study analyzed exhaled breath from a healthy adult population in Hawaii to profile the range of different volatile organic compounds (VOCs) and survey Hawaii-specific differences. The most consistently reported compounds in the breath profile of individuals were acetic acid, dimethoxymethane, benzoic acid methyl ester, and <i>n</i>-hexane. In comparison to other breathprinting studies, the list of compounds discovered was representative of control cohorts. This must be considered when implementing proposed breath diagnostics in new locations with increased interpersonal variation due to diversity. Further studies on larger numbers of subjects over longer periods of time will provide additional foundational data on baseline breath VOC profiles of control populations for comparison to disease-positive cohorts.https://www.mdpi.com/1420-3049/26/12/3726breath profilingcomprehensive two-dimensional gas chromatographyexhaled breathmetabolitesvolatile organic compoundspopulation in Hawaii |
| spellingShingle | Hunter R. Yamanaka Cynthia Cheung Jireh S. Mendoza Danson J. Oliva Kealina Elzey-Aberilla Katelynn A. Perrault Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii Molecules breath profiling comprehensive two-dimensional gas chromatography exhaled breath metabolites volatile organic compounds population in Hawaii |
| title | Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii |
| title_full | Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii |
| title_fullStr | Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii |
| title_full_unstemmed | Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii |
| title_short | Pilot Study on Exhaled Breath Analysis for a Healthy Adult Population in Hawaii |
| title_sort | pilot study on exhaled breath analysis for a healthy adult population in hawaii |
| topic | breath profiling comprehensive two-dimensional gas chromatography exhaled breath metabolites volatile organic compounds population in Hawaii |
| url | https://www.mdpi.com/1420-3049/26/12/3726 |
| work_keys_str_mv | AT hunterryamanaka pilotstudyonexhaledbreathanalysisforahealthyadultpopulationinhawaii AT cynthiacheung pilotstudyonexhaledbreathanalysisforahealthyadultpopulationinhawaii AT jirehsmendoza pilotstudyonexhaledbreathanalysisforahealthyadultpopulationinhawaii AT dansonjoliva pilotstudyonexhaledbreathanalysisforahealthyadultpopulationinhawaii AT kealinaelzeyaberilla pilotstudyonexhaledbreathanalysisforahealthyadultpopulationinhawaii AT katelynnaperrault pilotstudyonexhaledbreathanalysisforahealthyadultpopulationinhawaii |