Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal Function
Dysbiotic gut microbiome in chronic kidney disease (CKD) patients has been extensively explored in recent years. Skin microbiome plays a crucial role in patients with skin diseases or even systemic disorders. Pruritus is caused by the retention of uremic solutes in the skin. Until now, no studies ha...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.923581/full |
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| author | Yu Tian Chaoqun Gu Feng Yan Yifeng Gu Yangkun Feng Jie Chen Jiayi Sheng Lei Hu Peng Jiang Wei Guo Ninghan Feng |
| author_facet | Yu Tian Chaoqun Gu Feng Yan Yifeng Gu Yangkun Feng Jie Chen Jiayi Sheng Lei Hu Peng Jiang Wei Guo Ninghan Feng |
| author_sort | Yu Tian |
| collection | DOAJ |
| description | Dysbiotic gut microbiome in chronic kidney disease (CKD) patients has been extensively explored in recent years. Skin microbiome plays a crucial role in patients with skin diseases or even systemic disorders. Pruritus is caused by the retention of uremic solutes in the skin. Until now, no studies have investigated the role of skin microbiome in CKD and its association with pruritus. Here, we aim to examine the bacterial profile of skin microbiome in CKD and whether it is correlated to pruritus. A total of 105 CKD patients and 38 healthy controls (HC) were recruited. Skin swab was used to collect skin samples at the antecubital fossa of participants. Bacterial 16S rRNA genes V3–V4 region was sequenced on NovaSeq platform. On the day of skin sample collection, renal function was assessed, and numeric rating scale was used to measure pruritus severity. Principal coordinate analysis (PCoA) revealed a significant difference in bacterial composition between the groups of CKD and HC. A depletion of bacterial diversity was observed in CKD patients. Akkermansia, Albimonas, Escherichia–Shigella, etc. showed significant higher abundance in CKD patients, whereas Flavobacterium, Blastomonas, Lautropia, etc. significantly declined in patients. Escherichia–Shigella achieved an acceptable diagnostic biomarker with area under the curve (AUC) value of 0.784 in the receiver operating characteristics (ROC) curve. In addition, CKD patients with pruritus (P-CKD) had a different bacterial community comparing to those without pruritus (non-P-CKD) and HC group. Several bacterial genera showing significant difference between P-CKD and non-P-CKD/HC, such as Oribacterium, significantly declined in P-CKD patients than that in the HC group, and Methylophaga significantly increased in P-CKD patients compared to that in HC subjects. Escherichia–Shigella was positively associated with the levels of pruritus severity, blood urea nitrogen (BUN), uric acid, and urine protein; Oribacterium was negatively associated with pruritus severity, whereas it was positively associated with estimated glomerular filtration rate (eGFR) and 24-h urine volume. The dysbiotic of skin microbiome in CKD patients and its association with pruritus and renal function shed a light on skin probiotics. |
| first_indexed | 2024-04-13T19:14:20Z |
| format | Article |
| id | doaj.art-2f95ad27f6644f6994c9e67426927ab9 |
| institution | Directory Open Access Journal |
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| last_indexed | 2024-04-13T19:14:20Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-2f95ad27f6644f6994c9e67426927ab92022-12-22T02:33:43ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-06-011210.3389/fcimb.2022.923581923581Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal FunctionYu Tian0Chaoqun Gu1Feng Yan2Yifeng Gu3Yangkun Feng4Jie Chen5Jiayi Sheng6Lei Hu7Peng Jiang8Wei Guo9Ninghan Feng10Department of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDepartment of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDepartment of Nephrology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaSchool of Medicine, Nantong University, Nantong, ChinaDepartment of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDepartment of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDepartment of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDepartment of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDepartment of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDepartment of Urology, Wuxi No. 2 People’s Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, ChinaDysbiotic gut microbiome in chronic kidney disease (CKD) patients has been extensively explored in recent years. Skin microbiome plays a crucial role in patients with skin diseases or even systemic disorders. Pruritus is caused by the retention of uremic solutes in the skin. Until now, no studies have investigated the role of skin microbiome in CKD and its association with pruritus. Here, we aim to examine the bacterial profile of skin microbiome in CKD and whether it is correlated to pruritus. A total of 105 CKD patients and 38 healthy controls (HC) were recruited. Skin swab was used to collect skin samples at the antecubital fossa of participants. Bacterial 16S rRNA genes V3–V4 region was sequenced on NovaSeq platform. On the day of skin sample collection, renal function was assessed, and numeric rating scale was used to measure pruritus severity. Principal coordinate analysis (PCoA) revealed a significant difference in bacterial composition between the groups of CKD and HC. A depletion of bacterial diversity was observed in CKD patients. Akkermansia, Albimonas, Escherichia–Shigella, etc. showed significant higher abundance in CKD patients, whereas Flavobacterium, Blastomonas, Lautropia, etc. significantly declined in patients. Escherichia–Shigella achieved an acceptable diagnostic biomarker with area under the curve (AUC) value of 0.784 in the receiver operating characteristics (ROC) curve. In addition, CKD patients with pruritus (P-CKD) had a different bacterial community comparing to those without pruritus (non-P-CKD) and HC group. Several bacterial genera showing significant difference between P-CKD and non-P-CKD/HC, such as Oribacterium, significantly declined in P-CKD patients than that in the HC group, and Methylophaga significantly increased in P-CKD patients compared to that in HC subjects. Escherichia–Shigella was positively associated with the levels of pruritus severity, blood urea nitrogen (BUN), uric acid, and urine protein; Oribacterium was negatively associated with pruritus severity, whereas it was positively associated with estimated glomerular filtration rate (eGFR) and 24-h urine volume. The dysbiotic of skin microbiome in CKD patients and its association with pruritus and renal function shed a light on skin probiotics.https://www.frontiersin.org/articles/10.3389/fcimb.2022.923581/fullchronic kidney diseaseEscherichia–ShigellaOribacteriumpruritusrenal function |
| spellingShingle | Yu Tian Chaoqun Gu Feng Yan Yifeng Gu Yangkun Feng Jie Chen Jiayi Sheng Lei Hu Peng Jiang Wei Guo Ninghan Feng Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal Function Frontiers in Cellular and Infection Microbiology chronic kidney disease Escherichia–Shigella Oribacterium pruritus renal function |
| title | Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal Function |
| title_full | Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal Function |
| title_fullStr | Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal Function |
| title_full_unstemmed | Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal Function |
| title_short | Alteration of Skin Microbiome in CKD Patients Is Associated With Pruritus and Renal Function |
| title_sort | alteration of skin microbiome in ckd patients is associated with pruritus and renal function |
| topic | chronic kidney disease Escherichia–Shigella Oribacterium pruritus renal function |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.923581/full |
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