TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

Summary: Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function, but its precise role in this setting remains unclear. Quantitative proteomics was used to assess changes to the ER complex in response...

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Bibliographic Details
Main Authors: Rebecca Broome, Igor Chernukhin, Stacey Jamieson, Kamal Kishore, Evangelia K. Papachristou, Shi-Qing Mao, Carmen Gonzalez Tejedo, Areeb Mahtey, Vasiliki Theodorou, Arnoud J. Groen, Clive D’Santos, Shankar Balasubramanian, Anca Madalina Farcas, Rasmus Siersbæk, Jason S. Carroll
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
TET2
estrogen receptor
GATA3
5hmC
gene regulation
enhancers
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000899

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