Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension
<p>The aim of this work is to determine specificities of blood pressure (BP) numbers during the day depending on polymorphism of the A1166C-gene of angiotensin II receptor type I and T786C-promoter of the endothelial NO-synthase gene among residents of Ternopil region afflicted with essential...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2021-07-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/34806 |
| _version_ | 1818589853029236736 |
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| author | Roman Volodymyrovych Hnizdyukh Volodymyr Vasylovych Shmanko |
| author_facet | Roman Volodymyrovych Hnizdyukh Volodymyr Vasylovych Shmanko |
| author_sort | Roman Volodymyrovych Hnizdyukh |
| collection | DOAJ |
| description | <p>The aim of this work is to determine specificities of blood pressure (BP) numbers during the day depending on polymorphism of the A1166C-gene of angiotensin II receptor type I and T786C-promoter of the endothelial NO-synthase gene among residents of Ternopil region afflicted with essential arterial hypertension.</p><p>We have examined 86 patients with arterial hypertension who were treated and examined in the therapeutic department of the Central District Hospital in Kozova, aged from 45 to 76 years. All patients were measured for body weight and height, office blood pressure; also they were checked by Holter monitoring and electrocardiography (ECG), as well as examined for polymorphism of endothelial NO synthase genes and angiotensin II type 1 receptor genes. Statistical processing of the obtained data was performed with the help of the analytics software package including Statistica 8.0 (StatSoft Inc., USA) and Microsoft Office Excel-2003.</p><p>The research revealed that patients with CC genotype A1166C-gene of angiotensin II receptor of the first type had a significantly higher level of systolic blood pressure (SBP) and diastolic blood pressure (DBP) – average numbers per 24 hours, day and night – compared to patients with genotype AA(p<0,05). Hereby, no significant distinctions in blood pressure variability were found.</p><p>Patients with CC of the T786C promoter of the eNOs gene had higher SBP and DBP values at all times of the day compared to individuals with the TT genotype (p <0.05). Increased levels of variability of DBP during the day, as well as SBP and DBP at night, were observed among patients with CC genotype, as compared with the control group (p <0.05).</p><p>Among patients with C-allele of both studied genes, there’s a high frequency of circadian rhythm disorders with predominance of the “non-dippers” pathological type.</p> |
| first_indexed | 2024-12-16T09:47:14Z |
| format | Article |
| id | doaj.art-2f9740ac75bf4e23adc5d7856bb29927 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-16T09:47:14Z |
| publishDate | 2021-07-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-2f9740ac75bf4e23adc5d7856bb299272022-12-21T22:36:08ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062021-07-0111712413410.12775/3480627627Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertensionRoman Volodymyrovych Hnizdyukh0Volodymyr Vasylovych Shmanko1I. Ya. Horbachevsky Ternopil National Medical University 46001, 1 Maidan Voli, TernopilI. Ya. Horbachevsky Ternopil National Medical University 46001, 1 Maidan Voli, Ternopil<p>The aim of this work is to determine specificities of blood pressure (BP) numbers during the day depending on polymorphism of the A1166C-gene of angiotensin II receptor type I and T786C-promoter of the endothelial NO-synthase gene among residents of Ternopil region afflicted with essential arterial hypertension.</p><p>We have examined 86 patients with arterial hypertension who were treated and examined in the therapeutic department of the Central District Hospital in Kozova, aged from 45 to 76 years. All patients were measured for body weight and height, office blood pressure; also they were checked by Holter monitoring and electrocardiography (ECG), as well as examined for polymorphism of endothelial NO synthase genes and angiotensin II type 1 receptor genes. Statistical processing of the obtained data was performed with the help of the analytics software package including Statistica 8.0 (StatSoft Inc., USA) and Microsoft Office Excel-2003.</p><p>The research revealed that patients with CC genotype A1166C-gene of angiotensin II receptor of the first type had a significantly higher level of systolic blood pressure (SBP) and diastolic blood pressure (DBP) – average numbers per 24 hours, day and night – compared to patients with genotype AA(p<0,05). Hereby, no significant distinctions in blood pressure variability were found.</p><p>Patients with CC of the T786C promoter of the eNOs gene had higher SBP and DBP values at all times of the day compared to individuals with the TT genotype (p <0.05). Increased levels of variability of DBP during the day, as well as SBP and DBP at night, were observed among patients with CC genotype, as compared with the control group (p <0.05).</p><p>Among patients with C-allele of both studied genes, there’s a high frequency of circadian rhythm disorders with predominance of the “non-dippers” pathological type.</p>https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/34806arterial hypertensiongene polymorphismholter blood pressure monitoring. |
| spellingShingle | Roman Volodymyrovych Hnizdyukh Volodymyr Vasylovych Shmanko Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension Journal of Education, Health and Sport arterial hypertension gene polymorphism holter blood pressure monitoring. |
| title | Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension |
| title_full | Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension |
| title_fullStr | Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension |
| title_full_unstemmed | Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension |
| title_short | Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension |
| title_sort | specificity of blood pressure numbers in holter monitoring depending on gene polymorphism among residents of ternopil region afflicted with essential arterial hypertension |
| topic | arterial hypertension gene polymorphism holter blood pressure monitoring. |
| url | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/34806 |
| work_keys_str_mv | AT romanvolodymyrovychhnizdyukh specificityofbloodpressurenumbersinholtermonitoringdependingongenepolymorphismamongresidentsofternopilregionafflictedwithessentialarterialhypertension AT volodymyrvasylovychshmanko specificityofbloodpressurenumbersinholtermonitoringdependingongenepolymorphismamongresidentsofternopilregionafflictedwithessentialarterialhypertension |