The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma.

The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma.

Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis. FXR, a member of the metabolic nuclear receptor family, is markedly down-regulated in human CCA. Our aim was to evaluat...

Full description

Bibliographic Details
Main Authors: S Di Matteo, L Nevi, D Costantini, D Overi, G Carpino, S Safarikia, F Giulitti, C Napoletano, E Manzi, A M De Rose, F Melandro, M Bragazzi, P B Berloco, F Giuliante, G Grazi, A Giorgi, V Cardinale, L Adorini, E Gaudio, D Alvaro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210077

Internet

https://doi.org/10.1371/journal.pone.0210077

Similar Items