Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology?
Recent advances in neuroscience techniques and methods ushered in a new era in the research of neuronal function with unprecedented selectivity and temporal resolution. One of the main characteristics of these technical advances is the ability to selectively target and/or modulate specific neuronal...
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2023-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2023/0004-19632302109J.pdf |
| _version_ | 1797806087193231360 |
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| author | Joksimović Srđan M. Joksimović Sonja Lj |
| author_facet | Joksimović Srđan M. Joksimović Sonja Lj |
| author_sort | Joksimović Srđan M. |
| collection | DOAJ |
| description | Recent advances in neuroscience techniques and methods ushered in a new era in the research of neuronal function with unprecedented selectivity and temporal resolution. One of the main characteristics of these technical advances is the ability to selectively target and/or modulate specific neuronal subpopulations and circuits in both healthy and diseased brains. Although initially designed as tools to help researchers better understand the mechanisms underlying neuronal activity and complex behaviors, these novel approaches may also accelerate the process of drug discovery in many areas of neuroscience, and some may even potentially serve as novel therapeutic strategies. The application of different electrophysiological techniques is still considered essential in studying ion channel function and pharmacology, as well as network-level changes in brain activity. The cutting-edge methods for investigation of brain function include opto-and chemogenetics in freely behaving animals; both approaches enable highly selective control of neuronal activity using either a light stimulation (optogenetics) or a chemical ligand (chemogenetics) in both loss-and gain-of-function experiments. In this review paper, we aim to summarize recent scientific evidence on the state-of-the-art and provide information on these advances, taking into account both academic and pharmaceutical industry points of view. |
| first_indexed | 2024-03-13T06:01:59Z |
| format | Article |
| id | doaj.art-2f9a5103b9df49c5901759efe4ddabcc |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-03-13T06:01:59Z |
| publishDate | 2023-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-2f9a5103b9df49c5901759efe4ddabcc2023-06-12T11:18:04ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672023-01-017321091250004-19632302109JAdvanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology?Joksimović Srđan M.0Joksimović Sonja Lj1Children's Hospital of Philadelphia, Division of Neurology and CHOP Research Institute, PA, USAGlaxoSmithKline, Novel Human Genetics, Collegeville, PA, USARecent advances in neuroscience techniques and methods ushered in a new era in the research of neuronal function with unprecedented selectivity and temporal resolution. One of the main characteristics of these technical advances is the ability to selectively target and/or modulate specific neuronal subpopulations and circuits in both healthy and diseased brains. Although initially designed as tools to help researchers better understand the mechanisms underlying neuronal activity and complex behaviors, these novel approaches may also accelerate the process of drug discovery in many areas of neuroscience, and some may even potentially serve as novel therapeutic strategies. The application of different electrophysiological techniques is still considered essential in studying ion channel function and pharmacology, as well as network-level changes in brain activity. The cutting-edge methods for investigation of brain function include opto-and chemogenetics in freely behaving animals; both approaches enable highly selective control of neuronal activity using either a light stimulation (optogenetics) or a chemical ligand (chemogenetics) in both loss-and gain-of-function experiments. In this review paper, we aim to summarize recent scientific evidence on the state-of-the-art and provide information on these advances, taking into account both academic and pharmaceutical industry points of view.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2023/0004-19632302109J.pdfneurosciencedrug discoveryelectrophysiologyoptogeneticschemogenetics |
| spellingShingle | Joksimović Srđan M. Joksimović Sonja Lj Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology? Arhiv za farmaciju neuroscience drug discovery electrophysiology optogenetics chemogenetics |
| title | Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology? |
| title_full | Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology? |
| title_fullStr | Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology? |
| title_full_unstemmed | Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology? |
| title_short | Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology? |
| title_sort | advanced approaches for selective investigation of neuronal function and circuitry the future of developing novel therapeutic strategies in neuropharmacology |
| topic | neuroscience drug discovery electrophysiology optogenetics chemogenetics |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2023/0004-19632302109J.pdf |
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