Antiretroviral therapy of acute HIV-infection
Aim. To study efficacy of a short course of highly active antiretroviral therapy (HAART). Material and methods. Acute HIV infection was verified in 16 infected subjects basing either on seroconversion (by immunoblotting) or a documented negative result 6-12 months before registration of a positive r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2004-04-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29770 |
| _version_ | 1819100232078589952 |
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| author | A V Kravchenko A V Miroshnichenko V V Belyaeva L V Serebrovskaya E V Bogoslovskaya Yu R Sitdykova |
| author_facet | A V Kravchenko A V Miroshnichenko V V Belyaeva L V Serebrovskaya E V Bogoslovskaya Yu R Sitdykova |
| author_sort | A V Kravchenko |
| collection | DOAJ |
| description | Aim. To study efficacy of a short course of highly active antiretroviral therapy (HAART). Material and methods. Acute HIV infection was verified in 16 infected subjects basing either on seroconversion (by immunoblotting) or a documented negative result 6-12 months before registration of a positive result for HIV antibodies.
Results. HAART was given to 12 patients (combivir+nevirapin). The number of CD+ lymphocytes (by median) 1 month after the treatment increased by 185 cells/mcl, 3 months after the treatment - by 215 cells/mcl. After 1-month therapy viral load (median) diminished by 2,02 logl0 copy/ml, after 3 months - by 2,31 logw copy/ml. 71% patients had HIV RNA under 400 copy/ml. Untreated patients showed changes neither in CD4+lymphocytes number nor in viral load. The study continues. Conclusion. HAART is used at the stage of acute infection in the presence of psychic trauma provoked by establishment of HIV-infection diagnosis. Therefore, it is necessary to consult the patients for preparing them for treatment and to maintain compliance. |
| first_indexed | 2024-12-22T00:59:30Z |
| format | Article |
| id | doaj.art-2f9bbab430ca491b9e8ef8af83246947 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-22T00:59:30Z |
| publishDate | 2004-04-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-2f9bbab430ca491b9e8ef8af832469472022-12-21T18:44:14Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422004-04-01794151826798Antiretroviral therapy of acute HIV-infectionA V KravchenkoA V MiroshnichenkoV V BelyaevaL V SerebrovskayaE V BogoslovskayaYu R SitdykovaAim. To study efficacy of a short course of highly active antiretroviral therapy (HAART). Material and methods. Acute HIV infection was verified in 16 infected subjects basing either on seroconversion (by immunoblotting) or a documented negative result 6-12 months before registration of a positive result for HIV antibodies. Results. HAART was given to 12 patients (combivir+nevirapin). The number of CD+ lymphocytes (by median) 1 month after the treatment increased by 185 cells/mcl, 3 months after the treatment - by 215 cells/mcl. After 1-month therapy viral load (median) diminished by 2,02 logl0 copy/ml, after 3 months - by 2,31 logw copy/ml. 71% patients had HIV RNA under 400 copy/ml. Untreated patients showed changes neither in CD4+lymphocytes number nor in viral load. The study continues. Conclusion. HAART is used at the stage of acute infection in the presence of psychic trauma provoked by establishment of HIV-infection diagnosis. Therefore, it is necessary to consult the patients for preparing them for treatment and to maintain compliance.https://ter-arkhiv.ru/0040-3660/article/view/29770acute hiv-infectionhighly active antiretroviral therapycompliance to treatment |
| spellingShingle | A V Kravchenko A V Miroshnichenko V V Belyaeva L V Serebrovskaya E V Bogoslovskaya Yu R Sitdykova Antiretroviral therapy of acute HIV-infection Терапевтический архив acute hiv-infection highly active antiretroviral therapy compliance to treatment |
| title | Antiretroviral therapy of acute HIV-infection |
| title_full | Antiretroviral therapy of acute HIV-infection |
| title_fullStr | Antiretroviral therapy of acute HIV-infection |
| title_full_unstemmed | Antiretroviral therapy of acute HIV-infection |
| title_short | Antiretroviral therapy of acute HIV-infection |
| title_sort | antiretroviral therapy of acute hiv infection |
| topic | acute hiv-infection highly active antiretroviral therapy compliance to treatment |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29770 |
| work_keys_str_mv | AT avkravchenko antiretroviraltherapyofacutehivinfection AT avmiroshnichenko antiretroviraltherapyofacutehivinfection AT vvbelyaeva antiretroviraltherapyofacutehivinfection AT lvserebrovskaya antiretroviraltherapyofacutehivinfection AT evbogoslovskaya antiretroviraltherapyofacutehivinfection AT yursitdykova antiretroviraltherapyofacutehivinfection |