Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein

Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein

BackgroundTriple-negative breast cancer is a common malignant tumor with unfavorable prognosis affecting women worldwide; thus, there is an urgent need for novel therapeutic drugs with improved anti-tumor activity. Rac family small GTPase 1 (Rac1) plays an important role in malignant behavior and is...

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Bibliographic Details
Main Authors:	Xinxiao Li, Yunfeng Liu, Yuhua Zhao, Wei Tian, Lina Zhai, Huifeng Pang, Jiankang Kang, Huaxin Hou, Yanhua Chen, Danrong Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-05-01
Series:	Frontiers in Pharmacology
Subjects:	Rhein derivative drug design Rac family small GTPase 1 breast cancer anticancer
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00754/full

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