Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer

Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer

Ascorbate is a co-factor for the hydroxylases that regulate the transcription factor hypoxia-inducible factor (HIF)-1, which provides cancer cells with a metabolic and survival advantage in the hypoxic environment of solid tumors. However, whether ascorbate affects tumor development is a highly deba...

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Bibliographic Details
Main Authors: Caroline eKuiper, Gabi eDachs, Delwyn eMunn, Margaret eCurrie, Bridget eRobinson, John Frederick Pearson, Margreet C M Vissers
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Oncology
Subjects:
Hydroxylation
colorectal cancer
VEGF
ascorbate
hypoxia-inducible factor
BNIP3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00010/full

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