A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score
Aim to investigate whether the MAPH score, which is a new score that combines blood viscosity biomarkers such as mean platelet volume (MPV), total protein and hematocrit, can be used to predict thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients. Methods A total of 473 con...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296211073767 |
| _version_ | 1798021210655686656 |
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| author | Ozge Ozcan Abacioglu MD Arafat Yildirim MD Mine Karadeniz MD Serkan Abacioglu MD Nermin Yildiz Koyunsever MD Ferhat Dindas MD Mustafa Dogdus MD Mustafa Kaplangoray MD |
| author_facet | Ozge Ozcan Abacioglu MD Arafat Yildirim MD Mine Karadeniz MD Serkan Abacioglu MD Nermin Yildiz Koyunsever MD Ferhat Dindas MD Mustafa Dogdus MD Mustafa Kaplangoray MD |
| author_sort | Ozge Ozcan Abacioglu MD |
| collection | DOAJ |
| description | Aim to investigate whether the MAPH score, which is a new score that combines blood viscosity biomarkers such as mean platelet volume (MPV), total protein and hematocrit, can be used to predict thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients. Methods A total of 473 consecutive patients with STEMI were included in the study. Intracoronary tirofiban/abciximab infusion was applied to patients with thrombus load ≥3 and these patients (n = 71) were defined as the patient group with high thrombus load. MPV, age, hematocrit and total protein values of the patients were recorded. High shear rate (HSR) and low shear rate (LSR) were calculated from total protein and hematocrit values. Cut-off values were determined for high thrombus load by using Youden index, and score was determined as 0 or 1 according to cut-offs. The sum of the scores was calculated as the MAPH score. Results The mean age of the patients included in the study was 59.6 ± 12.6 (n = 354 male, 74.8%). There was no difference between the groups in terms of gender, HT and DM ( P = .127, P = .402 and P = .576, respectively). In the group with high thrombus load; total protein, MPV and hematocrit values were higher ( P < .001, P = .001 and P = .03, respectively). Comparison of receiver operating characteristic (ROC) curve analysis revealed that the MAPH score had better performance in predicting higher thrombus load than both other self-containing parameters and HSR and LSR. Conclusion The MAPH score may be a new score that can be used to determine thrombus burden in STEMI patients. |
| first_indexed | 2024-04-11T17:10:07Z |
| format | Article |
| id | doaj.art-2f9d72be040d4ace9c27066178d94087 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-04-11T17:10:07Z |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-2f9d72be040d4ace9c27066178d940872022-12-22T04:12:55ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-01-012810.1177/10760296211073767A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH ScoreOzge Ozcan Abacioglu MD0Arafat Yildirim MD1Mine Karadeniz MD2Serkan Abacioglu MD3Nermin Yildiz Koyunsever MD4Ferhat Dindas MD5Mustafa Dogdus MD6Mustafa Kaplangoray MD7 Adana City Training and Research Hospital, Adana, Turkey Adana City Training and Research Hospital, Adana, Turkey Hacettepe University, Ankara, Turkey Adana Yuregir State Hospital, Adana, Turkey Adana City Training and Research Hospital, Adana, Turkey , Usak, Turkey , Usak, Turkey Mehmet Akif İnan Training and Research Hospital, Sanlıurfa, TurkeyAim to investigate whether the MAPH score, which is a new score that combines blood viscosity biomarkers such as mean platelet volume (MPV), total protein and hematocrit, can be used to predict thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients. Methods A total of 473 consecutive patients with STEMI were included in the study. Intracoronary tirofiban/abciximab infusion was applied to patients with thrombus load ≥3 and these patients (n = 71) were defined as the patient group with high thrombus load. MPV, age, hematocrit and total protein values of the patients were recorded. High shear rate (HSR) and low shear rate (LSR) were calculated from total protein and hematocrit values. Cut-off values were determined for high thrombus load by using Youden index, and score was determined as 0 or 1 according to cut-offs. The sum of the scores was calculated as the MAPH score. Results The mean age of the patients included in the study was 59.6 ± 12.6 (n = 354 male, 74.8%). There was no difference between the groups in terms of gender, HT and DM ( P = .127, P = .402 and P = .576, respectively). In the group with high thrombus load; total protein, MPV and hematocrit values were higher ( P < .001, P = .001 and P = .03, respectively). Comparison of receiver operating characteristic (ROC) curve analysis revealed that the MAPH score had better performance in predicting higher thrombus load than both other self-containing parameters and HSR and LSR. Conclusion The MAPH score may be a new score that can be used to determine thrombus burden in STEMI patients.https://doi.org/10.1177/10760296211073767 |
| spellingShingle | Ozge Ozcan Abacioglu MD Arafat Yildirim MD Mine Karadeniz MD Serkan Abacioglu MD Nermin Yildiz Koyunsever MD Ferhat Dindas MD Mustafa Dogdus MD Mustafa Kaplangoray MD A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score Clinical and Applied Thrombosis/Hemostasis |
| title | A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score |
| title_full | A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score |
| title_fullStr | A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score |
| title_full_unstemmed | A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score |
| title_short | A New Score for Determining Thrombus Burden in STEMI Patients: The MAPH Score |
| title_sort | new score for determining thrombus burden in stemi patients the maph score |
| url | https://doi.org/10.1177/10760296211073767 |
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