Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN

Phosphatase and tensin homologue (PTEN), one of the well-characterized tumor suppressor proteins, counteracts the phosphatidylinositol 3-kinase-AKT pathway through its unique lipid phosphatase activity. The functions of PTEN are regulated by a variety of posttranslational modifications such as acety...

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Bibliographic Details
Main Authors: Makoto Nakakido, Zhenzhong Deng, Takehiro Suzuki, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558615000342

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