Oxidative Stress and Bio-Regulation
Reactive oxygen species (ROS) and free radicals work to maintain homeostasis in the body, but their excessive production causes damage to the organism. The human body is composed of a variety of cells totaling over 60 trillion cells. Each cell performs different functions and has a unique lifespan....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/6/3360 |
| _version_ | 1797240668533293056 |
|---|---|
| author | Toshikazu Yoshikawa Fukka You |
| author_facet | Toshikazu Yoshikawa Fukka You |
| author_sort | Toshikazu Yoshikawa |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) and free radicals work to maintain homeostasis in the body, but their excessive production causes damage to the organism. The human body is composed of a variety of cells totaling over 60 trillion cells. Each cell performs different functions and has a unique lifespan. The lifespan of cells is preprogrammed in their genes, and the death of cells that have reached the end of their lifespan is called apoptosis. This is contrary to necrosis, which is the premature death of cells brought about by physical or scientific forces. Each species has its own unique lifespan, which in humans is estimated to be up to 120 years. Elucidating the mechanism of the death of a single cell will lead to a better understanding of human death, and, conversely, the death of a single cell will lead to exploring the mechanisms of life. In this sense, research on active oxygen and free radicals, which are implicated in biological disorders and homeostasis, requires an understanding of both the physicochemical as well as the biochemical aspects. Based on the discussion above, it is clear to see that active oxygen and free radicals have dual functions of both injuring and facilitating homeostasis in living organisms. |
| first_indexed | 2024-04-24T18:11:05Z |
| format | Article |
| id | doaj.art-2f9fe1a6ef3946a5a0615449d3575ffd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:05Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2f9fe1a6ef3946a5a0615449d3575ffd2024-03-27T13:45:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256336010.3390/ijms25063360Oxidative Stress and Bio-RegulationToshikazu Yoshikawa0Fukka You1Louis Pasteur Center for Medical Research, Tanakamonzen-cho 103-5, Sakyo-ku, Kyoto 606-8225, JapanDivision of Anti-Oxidant Research, Life Science Research Center, Gifu University, Yanagito 1-1, Gifu 501-1194, JapanReactive oxygen species (ROS) and free radicals work to maintain homeostasis in the body, but their excessive production causes damage to the organism. The human body is composed of a variety of cells totaling over 60 trillion cells. Each cell performs different functions and has a unique lifespan. The lifespan of cells is preprogrammed in their genes, and the death of cells that have reached the end of their lifespan is called apoptosis. This is contrary to necrosis, which is the premature death of cells brought about by physical or scientific forces. Each species has its own unique lifespan, which in humans is estimated to be up to 120 years. Elucidating the mechanism of the death of a single cell will lead to a better understanding of human death, and, conversely, the death of a single cell will lead to exploring the mechanisms of life. In this sense, research on active oxygen and free radicals, which are implicated in biological disorders and homeostasis, requires an understanding of both the physicochemical as well as the biochemical aspects. Based on the discussion above, it is clear to see that active oxygen and free radicals have dual functions of both injuring and facilitating homeostasis in living organisms.https://www.mdpi.com/1422-0067/25/6/3360oxidative stressanti-oxidantfree radicalsbiochemistrybio-regulationreactive oxygen species |
| spellingShingle | Toshikazu Yoshikawa Fukka You Oxidative Stress and Bio-Regulation International Journal of Molecular Sciences oxidative stress anti-oxidant free radicals biochemistry bio-regulation reactive oxygen species |
| title | Oxidative Stress and Bio-Regulation |
| title_full | Oxidative Stress and Bio-Regulation |
| title_fullStr | Oxidative Stress and Bio-Regulation |
| title_full_unstemmed | Oxidative Stress and Bio-Regulation |
| title_short | Oxidative Stress and Bio-Regulation |
| title_sort | oxidative stress and bio regulation |
| topic | oxidative stress anti-oxidant free radicals biochemistry bio-regulation reactive oxygen species |
| url | https://www.mdpi.com/1422-0067/25/6/3360 |
| work_keys_str_mv | AT toshikazuyoshikawa oxidativestressandbioregulation AT fukkayou oxidativestressandbioregulation |