The protective effects of silymarin nanoemulsion on 5-fluorouracil-induced gastrointestinal toxicity in rats

The protective effects of silymarin nanoemulsion on 5-fluorouracil-induced gastrointestinal toxicity in rats

5-Fluorouracil (5FUra) is the third most popular chemotherapeutic component employed to treat solid tumors. In the present study, we aimed to appraise the silymarin (SM) and silymarin nanoemulsion (SMN) effect on 5FUra-induced gastrointestinal toxicity in adult male rats. A total of 30 male Wistar r...

Full description

Bibliographic Details
Main Authors:	Soheila Safarpour, Samaneh Safarpour, Ali Akbar Moghadamnia, Sohrab Kazemi, Anahita Ebrahimpour, Fatemeh Shirafkan
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Series:	Saudi Pharmaceutical Journal
Subjects:	Silymarin Gastrointestinal toxicity Oxidative stress IL-2 TNF-α 5-Fluorouracil
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319016423001573

Similar Items

Comparative Evaluation of the Preventive Effects of Citral, Silymarin, Thymoquinone, and Curcumin on 5-Fluorouracil-Induced Cardiac and Pulmonary Toxicity in Rats
by: Tohid Zahed, et al.
Published: (2024-12-01)

The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis
by: Mehrdad Shavandi, et al.
Published: (2022-12-01)

Autophagy in 5-Fluorouracil Therapy in Gastrointestinal Cancer: Trends and Challenges
by: Jia-Cheng Tang, et al.
Published: (2016-01-01)

Silymarin mitigates diclofenac-induced liver toxicity through inhibition of inflammation and oxidative stress in male rats
by: Pantea Ramezannezhad, et al.
Published: (2019-07-01)

Protective and anti-inflammatory effects of silymarin on paraquat-induced nephrotoxicity in rats
by: Ali Sharifi-Rigi, et al.
Published: (2019-01-01)

Studying the effect of silymarin against oxidative stress induced by chemotherapeutic protocol in breast cancer women
by: Bahir Abdul Razzaq, et al.
Published: (2011-12-01)

Risk factors for fluorouracil-induced cardiotoxicity in patients with gastrointestinal tumor
by: Yuting Wu, et al.
Published: (2025-02-01)

The comparison of the effects of nano-silymarin and silymarin on high-fat diet-induced fatty liver of adult male rats
by: Reza Mohebbati, et al.
Published: (2024-05-01)

Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload
by: adel abd elhaleim hagag
Published: (2014-08-01)

Antinociceptive Effect of Silymarin in Experimental Animals
by: *Ahmed S. Sahib,
Published: (2011-12-01)

Protective Effects of Alpha-Lipoic Acid against 5-Fluorouracil-Induced Gastrointestinal Mucositis in Rats
by: Deniz Ceylanlı, et al.
Published: (2022-09-01)

Silymarin and Inflammation: Food for Thoughts
by: Peter F. Surai, et al.
Published: (2024-01-01)

the effect of different doses of silymarin on gentamicin induced kidney damage in rats
by: nada. Naji Al-shawi, et al.
Published: (2005-10-01)

ALcoholic extraction of silymarin oil from seeds of local Milk thistle plant (silynum mariamum) at room temperature
by: Zainab Abdul whap Shahab, et al.
Published: (2019-12-01)

Protective effect of silymarin on tacrolimus-induced kidney and liver toxicity
by: Funda Terzi, et al.
Published: (2022-12-01)

2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases
by: Kateřina Valentová, et al.
Published: (2019-04-01)

Synthesis and Characterization of Chitosan-Decorated Nanoemulsion Gel of 5-Fluorouracil for Topical Delivery
by: Asif Nawaz, et al.
Published: (2022-06-01)

Comparison of Topical Silymarin with Hydroquinone in the Treatment of Melasma
by: Sumaira Abdullah, et al.
Published: (2022-03-01)

Hepato-Protective Effects of Silymarin and Coffee in Rats
by: Sidra Mumal, Akbar Waheed, Abdul Azeem, Hira Waqas Cheema, Fakhra Noureen, Abeera Zainab
Published: (2021-12-01)

Sequential changes of serum and liver subcellular oxidants and antioxidant concentrations in silymarin treated male rats
by: J.A.A. Al-Sa'aidi, et al.
Published: (2016-06-01)

Comparing Hepatoprotective Effects of Aqueous Extract of Cassia Fistula (Amaltas) Leaves and Silymarin
by: Rukhsana Munawar, Adnan Jehangir, Akbar Waheed
Published: (2021-11-01)

Preventive Effects of Silymarin on Diclofenac-induced Toxicity in the Domestic Pigeon (Columba livia)
by: Nasser Vajdi, et al.
Published: (2024-09-01)

Hepatoprotective effects of Silymarin in experimental aflatoxicosis in broiler chickens
by: Keleş Ömer Faruk, et al.
Published: (2025-02-01)

Effects of silymarin on hexaflumuron-induced lesions in rat kidneys
by: Amirmohammad Ghasempour, et al.
Published: (2024-03-01)

The effect of silymarin on ischemia-reperfusion injury in skeletal muscles of rats
by: Abdullah Ozer, et al.
Published: (2024-03-01)

Silymarin and Derivatives: From Biosynthesis to Health Benefits
by: Dominique Delmas
Published: (2020-05-01)

Silymarin Activates c-AMP Phosphodiesterase and Stimulates Insulin Secretion in a Glucose-Dependent Manner in HIT-T15 Cells
by: Ran Meng, et al.
Published: (2016-12-01)

Silymarin Modulates Microbiota in the Gut to Improve the Health of Sow from Late Gestation to Lactation
by: Shengyu Xu, et al.
Published: (2022-08-01)

Clinical role of silymarin in oxidative stress and infertility: A short review for pharmacy practitioners
by: Morvarid Zarif-Yeganeh, et al.
Published: (2019-01-01)

Potential gastrointestinal Behcet’s disease flare after treatment with anti-interleukin 17a therapy
by: Frances Sze Kei Sun, et al.
Published: (2023-08-01)

Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats
by: Arezoo Gohari Mahmoudabad, et al.
Published: (2023-07-01)

dose - dependent protective effects of silymarin against ccU - induced liver damage in rats
by: nada Naji AL-shAWI, et al.
Published: (2005-10-01)

Ameliorative effects of silymarin on aflatoxin B1 toxicity in weaned rabbits: impact on growth, blood profile, and oxidative stress
by: Tharwat A. Imbabi, et al.
Published: (2024-09-01)

Induction of Microsomal Liver Enzymes by Silymarin in Experimental Animals
by: Bahir A.R. Mshiemish, et al.
Published: (2011-07-01)

Study the analgesic effect of diclofenac and silymarin coadministration in chicks
by: Yasser M. Albadrany, et al.
Published: (2021-12-01)

Chemotherapeutic activity of Silymarin combined with doxorubicin liposomes in 4T1 breast cancer cells
by: Fatemeh Gheybi, et al.
Published: (2019-02-01)

Effects of silymarin and nano-silymarin on performance, egg quality, nutrient digestibility, and intestinal morphology of laying hens during storage
by: Samira Faryadi, et al.
Published: (2021-01-01)

Effects of gamma rays on rat testis tissue according to the morphological parameters and immunohistochemistry: radioprotective role of silymarin
by: Mohsen Marzban, et al.
Published: (2017-06-01)

Silymarin Effect on Mitophagy Pathway in the Human Colon Cancer HT-29 Cells
by: Layasadat Khorsandi, et al.
Published: (2022-12-01)

Therapeutic effect and molecular associated mechanisms of silymarin on osteoarthritis: A systematic review
by: Shahin Asgari Savadjani, et al.
Published: (2023-06-01)