Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices
This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM HgCl2 for 60 min at . 37℃. HgCl2 caused an in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2001-06-01
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| Series: | Journal of Pharmacopuncture |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3831/KPI.2001.4.2.049 |
| Summary: | This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM HgCl2 for 60 min at . 37℃. HgCl2 caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed Na+ ─ K+ATPase activity and ATP depletion. SbG prevented HgCl2-induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. HgCl2-induced inhibition of Na+ ─ K+-ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid. |
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| ISSN: | 2093-6966 2234-6856 |