Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices
This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM HgCl2 for 60 min at . 37℃. HgCl2 caused an in...
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2001-06-01
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| Series: | Journal of Pharmacopuncture |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3831/KPI.2001.4.2.049 |
| _version_ | 1818472573358309376 |
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| author | Hong-Soo Kim Choon-Ho Song |
| author_facet | Hong-Soo Kim Choon-Ho Song |
| author_sort | Hong-Soo Kim |
| collection | DOAJ |
| description | This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM HgCl2 for 60 min at . 37℃. HgCl2 caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed Na+ ─ K+ATPase activity and ATP depletion. SbG prevented HgCl2-induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. HgCl2-induced inhibition of Na+ ─ K+-ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid. |
| first_indexed | 2024-04-14T04:10:26Z |
| format | Article |
| id | doaj.art-2fa01674cfa44f9f9bc4a0f805b5c85c |
| institution | Directory Open Access Journal |
| issn | 2093-6966 2234-6856 |
| language | English |
| last_indexed | 2024-04-14T04:10:26Z |
| publishDate | 2001-06-01 |
| publisher | Korean Pharmacopuncture Institute |
| record_format | Article |
| series | Journal of Pharmacopuncture |
| spelling | doaj.art-2fa01674cfa44f9f9bc4a0f805b5c85c2022-12-22T02:13:13ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562001-06-0142495610.3831/KPI.2001.4.2.049 Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical SlicesHong-Soo Kim0Choon-Ho Song1Dept. of AM-Meridian & Pointology, College of Oriental Medicine, Dongeui UniversityDept. of AM-Meridian & Pointology, College of Oriental Medicine, Dongeui UniversityThis study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM HgCl2 for 60 min at . 37℃. HgCl2 caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed Na+ ─ K+ATPase activity and ATP depletion. SbG prevented HgCl2-induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. HgCl2-induced inhibition of Na+ ─ K+-ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid.http://dx.doi.org/10.3831/KPI.2001.4.2.049Scutellaria baicalensis GeorgiHgCl2Membrane transport dysfunctionRabbit renal cortical slicePAH uptakeNa+─K+─ATPase activityATP |
| spellingShingle | Hong-Soo Kim Choon-Ho Song Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices Journal of Pharmacopuncture Scutellaria baicalensis Georgi HgCl2 Membrane transport dysfunction Rabbit renal cortical slice PAH uptake Na+─K+─ATPase activity ATP |
| title | Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices |
| title_full | Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices |
| title_fullStr | Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices |
| title_full_unstemmed | Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices |
| title_short | Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices |
| title_sort | beneficial effect of scutellaria baicalensis georgi extract on mercury chloride induced membrane transport dysfunction in rabbit renal cortical slices |
| topic | Scutellaria baicalensis Georgi HgCl2 Membrane transport dysfunction Rabbit renal cortical slice PAH uptake Na+─K+─ATPase activity ATP |
| url | http://dx.doi.org/10.3831/KPI.2001.4.2.049 |
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