Hepatitis C Treatment: A Review and Update
Hepatitis C virus infection (HCV) infects approximately 185 million individuals worldwide. It is a leading cause of chronic liver disease and the primary reason for liver transplantation. The main aim of antiviral treatment is to achieve a sustained virologic response, which means eradication of the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Osijek
2017-04-01
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| Series: | Southeastern European Medical Journal |
| Subjects: | |
| Online Access: | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/seemed17103/5 |
| _version_ | 1811281764585308160 |
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| author | Jelena Jakab Marinko Žulj Nikola Volarić Bojan Tepeš Aleksandar Včev |
| author_facet | Jelena Jakab Marinko Žulj Nikola Volarić Bojan Tepeš Aleksandar Včev |
| author_sort | Jelena Jakab |
| collection | DOAJ |
| description | Hepatitis C virus infection (HCV) infects approximately 185 million individuals worldwide. It is a leading cause of chronic liver disease and the primary reason for liver transplantation. The main aim of antiviral treatment is to achieve a sustained virologic response, which means eradication of the virus. The combination of pegylated-interferon and ribavirin was the standard of care for over a decade, despite the long treatment duration and severe adverse effects. The introduction of direct-acting antivirals with pan-genomic properties and excellent tolerance increased rates of SVR and shortened the duration of the therapy. Furthermore, it allowed clinicians to customise HCV therapy according to important clinical parameters such as HCV- genotype and liver fibrosis stage. |
| first_indexed | 2024-04-13T01:39:30Z |
| format | Article |
| id | doaj.art-2fa0ebf2990245fdbb1c811b670c1fe5 |
| institution | Directory Open Access Journal |
| issn | 2459-9484 |
| language | English |
| last_indexed | 2024-04-13T01:39:30Z |
| publishDate | 2017-04-01 |
| publisher | Faculty of Medicine Osijek |
| record_format | Article |
| series | Southeastern European Medical Journal |
| spelling | doaj.art-2fa0ebf2990245fdbb1c811b670c1fe52022-12-22T03:08:14ZengFaculty of Medicine OsijekSoutheastern European Medical Journal2459-94842017-04-0111111810.26332/seemedj.v1i1.27Hepatitis C Treatment: A Review and UpdateJelena Jakab0Marinko Žulj1Nikola Volarić2Bojan Tepeš3Aleksandar Včev4Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaHepatitis C virus infection (HCV) infects approximately 185 million individuals worldwide. It is a leading cause of chronic liver disease and the primary reason for liver transplantation. The main aim of antiviral treatment is to achieve a sustained virologic response, which means eradication of the virus. The combination of pegylated-interferon and ribavirin was the standard of care for over a decade, despite the long treatment duration and severe adverse effects. The introduction of direct-acting antivirals with pan-genomic properties and excellent tolerance increased rates of SVR and shortened the duration of the therapy. Furthermore, it allowed clinicians to customise HCV therapy according to important clinical parameters such as HCV- genotype and liver fibrosis stage.http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/seemed17103/5hepatitis C infectiontreatmentdirect - acting antivirals |
| spellingShingle | Jelena Jakab Marinko Žulj Nikola Volarić Bojan Tepeš Aleksandar Včev Hepatitis C Treatment: A Review and Update Southeastern European Medical Journal hepatitis C infection treatment direct - acting antivirals |
| title | Hepatitis C Treatment: A Review and Update |
| title_full | Hepatitis C Treatment: A Review and Update |
| title_fullStr | Hepatitis C Treatment: A Review and Update |
| title_full_unstemmed | Hepatitis C Treatment: A Review and Update |
| title_short | Hepatitis C Treatment: A Review and Update |
| title_sort | hepatitis c treatment a review and update |
| topic | hepatitis C infection treatment direct - acting antivirals |
| url | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/seemed17103/5 |
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