MERCs. The Novel Assistant to Neurotransmission?
In neuroscience, much attention is paid to intercellular interactions, in particular, to synapses. However, many researchers do not pay due attention to the contribution of intracellular contacts to the work of intercellular interactions. Nevertheless, along with synapses, intracellular contacts als...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2020.589319/full |
| _version_ | 1819204476849881088 |
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| author | Olesya M. Shirokova Pavel V. Pchelin Pavel V. Pchelin Irina V. Mukhina Irina V. Mukhina |
| author_facet | Olesya M. Shirokova Pavel V. Pchelin Pavel V. Pchelin Irina V. Mukhina Irina V. Mukhina |
| author_sort | Olesya M. Shirokova |
| collection | DOAJ |
| description | In neuroscience, much attention is paid to intercellular interactions, in particular, to synapses. However, many researchers do not pay due attention to the contribution of intracellular contacts to the work of intercellular interactions. Nevertheless, along with synapses, intracellular contacts also have complex organization and a tremendous number of regulatory elements. Mitochondria-endoplasmic reticulum contacts (MERCs) are a specific site of interaction between the two organelles; they provide a basis for a large number of cellular functions, such as calcium homeostasis, lipid metabolism, autophagy, and apoptosis. Despite the presence of these contacts in various parts of neurons and glial cells, it is yet not known whether they fulfill the same functions. There are still many unsolved questions about the work of these intracellular contacts, and one of the most important among them is if MERCs, with their broad implication into synaptic events, can be considered the assistant to neurotransmission? |
| first_indexed | 2024-12-23T04:36:25Z |
| format | Article |
| id | doaj.art-2fa1c86628144c0ba663770287ae0301 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-23T04:36:25Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2fa1c86628144c0ba663770287ae03012022-12-21T17:59:53ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-11-011410.3389/fnins.2020.589319589319MERCs. The Novel Assistant to Neurotransmission?Olesya M. Shirokova0Pavel V. Pchelin1Pavel V. Pchelin2Irina V. Mukhina3Irina V. Mukhina4Central Scientific Research Laboratory, Institute of Fundamental Medicine, Privolzhsky Research Medical University, Nizhny Novgorod, RussiaCentral Scientific Research Laboratory, Institute of Fundamental Medicine, Privolzhsky Research Medical University, Nizhny Novgorod, RussiaDepartment of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, RussiaCentral Scientific Research Laboratory, Institute of Fundamental Medicine, Privolzhsky Research Medical University, Nizhny Novgorod, RussiaDepartment of Neurotechnology, Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, RussiaIn neuroscience, much attention is paid to intercellular interactions, in particular, to synapses. However, many researchers do not pay due attention to the contribution of intracellular contacts to the work of intercellular interactions. Nevertheless, along with synapses, intracellular contacts also have complex organization and a tremendous number of regulatory elements. Mitochondria-endoplasmic reticulum contacts (MERCs) are a specific site of interaction between the two organelles; they provide a basis for a large number of cellular functions, such as calcium homeostasis, lipid metabolism, autophagy, and apoptosis. Despite the presence of these contacts in various parts of neurons and glial cells, it is yet not known whether they fulfill the same functions. There are still many unsolved questions about the work of these intracellular contacts, and one of the most important among them is if MERCs, with their broad implication into synaptic events, can be considered the assistant to neurotransmission?https://www.frontiersin.org/articles/10.3389/fnins.2020.589319/fullsynapseendoplasmic reticulummitochondria-endoplasmic reticulum contactscalcium homeostasisneurodegenerative diseasessynaptic transmission |
| spellingShingle | Olesya M. Shirokova Pavel V. Pchelin Pavel V. Pchelin Irina V. Mukhina Irina V. Mukhina MERCs. The Novel Assistant to Neurotransmission? Frontiers in Neuroscience synapse endoplasmic reticulum mitochondria-endoplasmic reticulum contacts calcium homeostasis neurodegenerative diseases synaptic transmission |
| title | MERCs. The Novel Assistant to Neurotransmission? |
| title_full | MERCs. The Novel Assistant to Neurotransmission? |
| title_fullStr | MERCs. The Novel Assistant to Neurotransmission? |
| title_full_unstemmed | MERCs. The Novel Assistant to Neurotransmission? |
| title_short | MERCs. The Novel Assistant to Neurotransmission? |
| title_sort | mercs the novel assistant to neurotransmission |
| topic | synapse endoplasmic reticulum mitochondria-endoplasmic reticulum contacts calcium homeostasis neurodegenerative diseases synaptic transmission |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2020.589319/full |
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