Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, Spain
The use of pneumococcal conjugate vaccines has affected the epidemiology and distribution of <i>Streptococcus pneumoniae</i> serotypes causing Invasive Pneumococcal Disease (IPD). The aim of this study was to analyze the evolution of the phenotypical profiles of antimicrobial susceptibil...
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MDPI AG
2023-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/2/289 |
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| author | Sara de Miguel Marta Pérez-Abeledo Belén Ramos Luis García Araceli Arce Rodrigo Martínez-Arce Jose Yuste Juan Carlos Sanz |
| author_facet | Sara de Miguel Marta Pérez-Abeledo Belén Ramos Luis García Araceli Arce Rodrigo Martínez-Arce Jose Yuste Juan Carlos Sanz |
| author_sort | Sara de Miguel |
| collection | DOAJ |
| description | The use of pneumococcal conjugate vaccines has affected the epidemiology and distribution of <i>Streptococcus pneumoniae</i> serotypes causing Invasive Pneumococcal Disease (IPD). The aim of this study was to analyze the evolution of the phenotypical profiles of antimicrobial susceptibility to penicillin (PEN) in all IPD strains isolated in Madrid, Spain, during 2007–2021. In total, 7133 invasive clinical isolates were characterized between 2007 and 2021. Levels of PENR and PNSSDR were 2.0% and 24.2%, respectively. In addition, 94.4% of all the PENR belonged to four serotypes, including 11A (33.6%), 19A (30.8%), 14 (20.3%) and 9V (9.8%). All the strains of serotype 11A, which is a non-PCV13 serotype, were detected after the year 2011. Serotypes 6C, 15A, 23B, 24F, 35B, 19F, 16F, 6B, 23F, 24B, 24A, 15F and a limited number of strains of serogroups 16 and 24 (non-typed at serotype level) were associated with PNSSDR (<i>p</i> < 0.05). PNSSDR strains of non-PCV13 serotypes 11A, 24F, 23B, 24B, 23A and 16F were more frequent from 2014 to 2021. The changes in <i>S. pneumoniae</i> serotype distribution associated with the use of conjugate vaccines had caused in our region the emergence of non-PCV13 pneumococcal strains with different PENR or PNSSDR patterns. The emergence of serotype 11A resistant to penicillin as the most important non-PCV13 serotype is a worrisome event with marked relevance from the clinical and epidemiological perspective. |
| first_indexed | 2024-03-11T09:14:47Z |
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| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:14:47Z |
| publishDate | 2023-02-01 |
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| series | Antibiotics |
| spelling | doaj.art-2fa2d395d84e4f35a7751d8fd7f038412023-11-16T18:43:00ZengMDPI AGAntibiotics2079-63822023-02-0112228910.3390/antibiotics12020289Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, SpainSara de Miguel0Marta Pérez-Abeledo1Belén Ramos2Luis García3Araceli Arce4Rodrigo Martínez-Arce5Jose Yuste6Juan Carlos Sanz7Epidemiology Department, Directorate General of Public Health, Regional Ministry of Health of Madrid, 28002 Madrid, SpainClinical Microbiology Unit, Public Health Regional Laboratory of the Community of Madrid, Directorate General of Public Health, Regional Ministry of Health of Madrid, 28055 Madrid, SpainClinical Microbiology Unit, Public Health Regional Laboratory of the Community of Madrid, Directorate General of Public Health, Regional Ministry of Health of Madrid, 28055 Madrid, SpainEpidemiology Department, Directorate General of Public Health, Regional Ministry of Health of Madrid, 28002 Madrid, SpainEpidemiology Department, Directorate General of Public Health, Regional Ministry of Health of Madrid, 28002 Madrid, SpainClinical Microbiology Unit, Public Health Regional Laboratory of the Community of Madrid, Directorate General of Public Health, Regional Ministry of Health of Madrid, 28055 Madrid, SpainCIBER of Respiratory Diseases (CIBERES), 28029 Madrid, SpainClinical Microbiology Unit, Public Health Regional Laboratory of the Community of Madrid, Directorate General of Public Health, Regional Ministry of Health of Madrid, 28055 Madrid, SpainThe use of pneumococcal conjugate vaccines has affected the epidemiology and distribution of <i>Streptococcus pneumoniae</i> serotypes causing Invasive Pneumococcal Disease (IPD). The aim of this study was to analyze the evolution of the phenotypical profiles of antimicrobial susceptibility to penicillin (PEN) in all IPD strains isolated in Madrid, Spain, during 2007–2021. In total, 7133 invasive clinical isolates were characterized between 2007 and 2021. Levels of PENR and PNSSDR were 2.0% and 24.2%, respectively. In addition, 94.4% of all the PENR belonged to four serotypes, including 11A (33.6%), 19A (30.8%), 14 (20.3%) and 9V (9.8%). All the strains of serotype 11A, which is a non-PCV13 serotype, were detected after the year 2011. Serotypes 6C, 15A, 23B, 24F, 35B, 19F, 16F, 6B, 23F, 24B, 24A, 15F and a limited number of strains of serogroups 16 and 24 (non-typed at serotype level) were associated with PNSSDR (<i>p</i> < 0.05). PNSSDR strains of non-PCV13 serotypes 11A, 24F, 23B, 24B, 23A and 16F were more frequent from 2014 to 2021. The changes in <i>S. pneumoniae</i> serotype distribution associated with the use of conjugate vaccines had caused in our region the emergence of non-PCV13 pneumococcal strains with different PENR or PNSSDR patterns. The emergence of serotype 11A resistant to penicillin as the most important non-PCV13 serotype is a worrisome event with marked relevance from the clinical and epidemiological perspective.https://www.mdpi.com/2079-6382/12/2/289<i>Streptococcus pneumoniae</i>serotypesantimicrobial susceptibilityresistancepenicillin |
| spellingShingle | Sara de Miguel Marta Pérez-Abeledo Belén Ramos Luis García Araceli Arce Rodrigo Martínez-Arce Jose Yuste Juan Carlos Sanz Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, Spain Antibiotics <i>Streptococcus pneumoniae</i> serotypes antimicrobial susceptibility resistance penicillin |
| title | Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, Spain |
| title_full | Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, Spain |
| title_fullStr | Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, Spain |
| title_full_unstemmed | Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, Spain |
| title_short | Evolution of Antimicrobial Susceptibility to Penicillin in Invasive Strains of <i>Streptococcus pneumoniae</i> during 2007–2021 in Madrid, Spain |
| title_sort | evolution of antimicrobial susceptibility to penicillin in invasive strains of i streptococcus pneumoniae i during 2007 2021 in madrid spain |
| topic | <i>Streptococcus pneumoniae</i> serotypes antimicrobial susceptibility resistance penicillin |
| url | https://www.mdpi.com/2079-6382/12/2/289 |
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