The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy
Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the key target and effector cells in its pathogenesis. The...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2019-07-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2019/7/20190724.pdf |
| _version_ | 1818842388327563264 |
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| author | Zhen-Mao Wang Zheng-Yan Wang Yan Lu |
| author_facet | Zhen-Mao Wang Zheng-Yan Wang Yan Lu |
| author_sort | Zhen-Mao Wang |
| collection | DOAJ |
| description | Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the key target and effector cells in its pathogenesis. The orbit infiltrating CD34+ fibrocytes add on to the process by expressing high levels of autoantigens and inflammatory cytokines, while also differentiating into myofibroblasts or adipocytes. This review focuses on the role of orbital fibroblasts and CD34+ fibrocytes in the pathogenesis of TAO, highlighting the basis of emerging treatments. |
| first_indexed | 2024-12-19T04:41:11Z |
| format | Article |
| id | doaj.art-2fa31796850d40a8bd8c36a59972b36a |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-19T04:41:11Z |
| publishDate | 2019-07-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-2fa31796850d40a8bd8c36a59972b36a2022-12-21T20:35:36ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982019-07-011271209121410.18240/ijo.2019.07.24The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathyZhen-Mao Wang0Zheng-Yan Wang1Yan Lu2Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou 515000, Guangdong Province, ChinaThe People’s Hospital of Xintai, Xintai 271200, Shandong Province, ChinaDepartment of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, ChinaCurrently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the key target and effector cells in its pathogenesis. The orbit infiltrating CD34+ fibrocytes add on to the process by expressing high levels of autoantigens and inflammatory cytokines, while also differentiating into myofibroblasts or adipocytes. This review focuses on the role of orbital fibroblasts and CD34+ fibrocytes in the pathogenesis of TAO, highlighting the basis of emerging treatments.http://www.ijo.cn/en_publish/2019/7/20190724.pdfthyroid-associated ophthalmopathyorbital fibroblastfibrocytesimmunopathogenesis |
| spellingShingle | Zhen-Mao Wang Zheng-Yan Wang Yan Lu The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy International Journal of Ophthalmology thyroid-associated ophthalmopathy orbital fibroblast fibrocytes immunopathogenesis |
| title | The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy |
| title_full | The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy |
| title_fullStr | The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy |
| title_full_unstemmed | The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy |
| title_short | The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy |
| title_sort | role of cell mediated immunopathogenesis in thyroid associated ophthalmopathy |
| topic | thyroid-associated ophthalmopathy orbital fibroblast fibrocytes immunopathogenesis |
| url | http://www.ijo.cn/en_publish/2019/7/20190724.pdf |
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