The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step
WbbB is a structurally unusual retaining glycosyltransferase. Here, the authors show that WbbB forms an Asp232-Kdo adduct prior to transfer to the saccharide acceptor. Therefore, unlike any previously studied glycosyltransferase, WbbB uses the double-displacement mechanism first proposed in 1953.
Main Authors: | Taylor J. B. Forrester, Olga G. Ovchinnikova, Zhixiong Li, Elena N. Kitova, Jeremy T. Nothof, Akihiko Koizumi, John S. Klassen, Todd L. Lowary, Chris Whitfield, Matthew S. Kimber |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-33988-1 |
Similar Items
-
Author Correction: The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step
by: Taylor J. B. Forrester, et al.
Published: (2022-12-01) -
Uvodnik: kolektivna krivda – kdo je kdo v zdravstvu
by: Petra Kersnič
Published: (2003-06-01) -
Kdo so bili moji mentorji? kdo mi je lahko mentor?
by: Ana Krajnc
Published: (2006-12-01) -
Kdo danes potrebuje Turgenjeva
by: Blaž Podlesnik
Published: (2022-11-01) -
Kdo se boji disleksije?
by: Dušana Findeisen
Published: (1996-12-01)