Different glaucoma progression rates by age groups in young myopic glaucoma patients
Abstract We aimed to investigate the age-related glaucoma progression rates in myopic normal tension glaucoma (NTG). In this long-term retrospective cohort (7.2 ± 3.5 years), we grouped patients based on their age at initial presentation: group A (age < 30 years, 60 eyes), group B (30 ≤ age < ...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53133-w |
| _version_ | 1827327696164618240 |
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| author | Eun Jung Lee Dongyoung Lee Min-Ji Kim Kyunga Kim Jong Chul Han Changwon Kee |
| author_facet | Eun Jung Lee Dongyoung Lee Min-Ji Kim Kyunga Kim Jong Chul Han Changwon Kee |
| author_sort | Eun Jung Lee |
| collection | DOAJ |
| description | Abstract We aimed to investigate the age-related glaucoma progression rates in myopic normal tension glaucoma (NTG). In this long-term retrospective cohort (7.2 ± 3.5 years), we grouped patients based on their age at initial presentation: group A (age < 30 years, 60 eyes), group B (30 ≤ age < 40, 66 eyes), and group C (40 ≤ age < 50 years, 63 eyes). We used a linear mixed-effects model to estimate retinal nerve fiber layer (RNFL) defect width enlargement rates. Group A showed a significantly faster rate of RNFL defect progression (3.01 ± 1.74°/year) than those of groups B and C (2.05 ± 1.55°/year and 2.06 ± 1.29°/year, P = 0.004 and 0.002). The difference was more marked when calculated for the first 10 years of follow-up in group A, B, and C (3.95 ± 2.70°/year, 2.39 ± 1.64°/year, and 1.98 ± 1.31°/year), and between the periods of age < 30 years, 30 ≤ age < 40 years, and 40 ≤ age < 50 years within group A. This is the first evidence of rapid glaucoma progression in the young adulthood and stabilization in older age in myopic NTG. Clinicians should consider the potentially aggressive course of glaucoma, especially in younger patients with myopic NTG, in contrast to the general slow progression in adulthood. |
| first_indexed | 2024-03-07T15:05:04Z |
| format | Article |
| id | doaj.art-2fa3cef85d8d4fbb8859bc64aeba9ece |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:05:04Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2fa3cef85d8d4fbb8859bc64aeba9ece2024-03-05T18:56:04ZengNature PortfolioScientific Reports2045-23222024-01-011411910.1038/s41598-024-53133-wDifferent glaucoma progression rates by age groups in young myopic glaucoma patientsEun Jung Lee0Dongyoung Lee1Min-Ji Kim2Kyunga Kim3Jong Chul Han4Changwon Kee5Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineBiomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical CenterBiomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical CenterDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Ophthalmology, Kim’s Eye Hospital, Konyang University College of MedicineAbstract We aimed to investigate the age-related glaucoma progression rates in myopic normal tension glaucoma (NTG). In this long-term retrospective cohort (7.2 ± 3.5 years), we grouped patients based on their age at initial presentation: group A (age < 30 years, 60 eyes), group B (30 ≤ age < 40, 66 eyes), and group C (40 ≤ age < 50 years, 63 eyes). We used a linear mixed-effects model to estimate retinal nerve fiber layer (RNFL) defect width enlargement rates. Group A showed a significantly faster rate of RNFL defect progression (3.01 ± 1.74°/year) than those of groups B and C (2.05 ± 1.55°/year and 2.06 ± 1.29°/year, P = 0.004 and 0.002). The difference was more marked when calculated for the first 10 years of follow-up in group A, B, and C (3.95 ± 2.70°/year, 2.39 ± 1.64°/year, and 1.98 ± 1.31°/year), and between the periods of age < 30 years, 30 ≤ age < 40 years, and 40 ≤ age < 50 years within group A. This is the first evidence of rapid glaucoma progression in the young adulthood and stabilization in older age in myopic NTG. Clinicians should consider the potentially aggressive course of glaucoma, especially in younger patients with myopic NTG, in contrast to the general slow progression in adulthood.https://doi.org/10.1038/s41598-024-53133-w |
| spellingShingle | Eun Jung Lee Dongyoung Lee Min-Ji Kim Kyunga Kim Jong Chul Han Changwon Kee Different glaucoma progression rates by age groups in young myopic glaucoma patients Scientific Reports |
| title | Different glaucoma progression rates by age groups in young myopic glaucoma patients |
| title_full | Different glaucoma progression rates by age groups in young myopic glaucoma patients |
| title_fullStr | Different glaucoma progression rates by age groups in young myopic glaucoma patients |
| title_full_unstemmed | Different glaucoma progression rates by age groups in young myopic glaucoma patients |
| title_short | Different glaucoma progression rates by age groups in young myopic glaucoma patients |
| title_sort | different glaucoma progression rates by age groups in young myopic glaucoma patients |
| url | https://doi.org/10.1038/s41598-024-53133-w |
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