ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell
Gastric cancer (GC), a common type of malignant cancer, remains the fifth most frequently diagnosed cancer and the third leading cause of cancer-related deaths worldwide. Despite developments in the treatment of GC, the prognosis remains poor. Embryonic stem cell-expressed Ras (ERas), a novel member...
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| Format: | Article |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2019.00375/full |
| _version_ | 1818280428711182336 |
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| author | Huajian Tian Wenjun Wang Xiao Meng Miaomiao Wang Junyang Tan Wenjuan Jia Peining Li Jianshuang Li Qinghua Zhou |
| author_facet | Huajian Tian Wenjun Wang Xiao Meng Miaomiao Wang Junyang Tan Wenjuan Jia Peining Li Jianshuang Li Qinghua Zhou |
| author_sort | Huajian Tian |
| collection | DOAJ |
| description | Gastric cancer (GC), a common type of malignant cancer, remains the fifth most frequently diagnosed cancer and the third leading cause of cancer-related deaths worldwide. Despite developments in the treatment of GC, the prognosis remains poor. Embryonic stem cell-expressed Ras (ERas), a novel member of the Ras protein family, has recently been identified as an oncogene involved in the tumorigenic growth of embryonic stem cells. A recent study reported that ERas is expressed in most GC cell lines and GC specimens, and it promotes tumorigenicity in GC through induction of the epithelial mesenchymal transition (EMT) and activation of the PI3K/AKT pathway. Here, we found that ERas blocked autophagy flux in BGC-823 and AGS GC cells, which may occur through activation of the AKT/mTOR signaling pathway. Moreover, ERas overexpression suppressed cisplatin-induced apoptosis, and rapamycin treatment significantly attenuated ERas-mediated cisplatin resistance in GC cells. These data suggest that ERas may be a potential therapeutic target to improve the outcomes of GC patients by regulating the autophagy process. |
| first_indexed | 2024-12-12T23:49:04Z |
| format | Article |
| id | doaj.art-2fa7225ee1454afba73b1fd365748c4e |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T23:49:04Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-2fa7225ee1454afba73b1fd365748c4e2022-12-22T00:06:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-01-01710.3389/fcell.2019.00375493590ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer CellHuajian Tian0Wenjun Wang1Xiao Meng2Miaomiao Wang3Junyang Tan4Wenjuan Jia5Peining Li6Jianshuang Li7Qinghua Zhou8The First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, ChinaThe First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, ChinaThe First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, ChinaThe First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, ChinaThe First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, ChinaQingyuan People’s Hospital, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, ChinaDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, United StatesThe First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, ChinaThe First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, ChinaGastric cancer (GC), a common type of malignant cancer, remains the fifth most frequently diagnosed cancer and the third leading cause of cancer-related deaths worldwide. Despite developments in the treatment of GC, the prognosis remains poor. Embryonic stem cell-expressed Ras (ERas), a novel member of the Ras protein family, has recently been identified as an oncogene involved in the tumorigenic growth of embryonic stem cells. A recent study reported that ERas is expressed in most GC cell lines and GC specimens, and it promotes tumorigenicity in GC through induction of the epithelial mesenchymal transition (EMT) and activation of the PI3K/AKT pathway. Here, we found that ERas blocked autophagy flux in BGC-823 and AGS GC cells, which may occur through activation of the AKT/mTOR signaling pathway. Moreover, ERas overexpression suppressed cisplatin-induced apoptosis, and rapamycin treatment significantly attenuated ERas-mediated cisplatin resistance in GC cells. These data suggest that ERas may be a potential therapeutic target to improve the outcomes of GC patients by regulating the autophagy process.https://www.frontiersin.org/article/10.3389/fcell.2019.00375/fullgastric cancerERasautophagyapoptosisresistance |
| spellingShingle | Huajian Tian Wenjun Wang Xiao Meng Miaomiao Wang Junyang Tan Wenjuan Jia Peining Li Jianshuang Li Qinghua Zhou ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell Frontiers in Cell and Developmental Biology gastric cancer ERas autophagy apoptosis resistance |
| title | ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell |
| title_full | ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell |
| title_fullStr | ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell |
| title_full_unstemmed | ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell |
| title_short | ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell |
| title_sort | eras enhances resistance to cisplatin induced apoptosis by suppressing autophagy in gastric cancer cell |
| topic | gastric cancer ERas autophagy apoptosis resistance |
| url | https://www.frontiersin.org/article/10.3389/fcell.2019.00375/full |
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