Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score
Objective: Although the early use of a risk stratification score in gastrointestinal bleeding (GIB) is recommended, so far there has been no risk score for GIB in patients admitted to the cardiology department. To describe the risk factors of GIB and develop a new risk score model in patients admitt...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Hellenic Journal of Cardiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1109966620301639 |
| _version_ | 1828920383183519744 |
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| author | Ming Zhang Demin Liu Qian Wang Xue Geng Qian Hou Guoqiang Gu Ruiqin Xie Wei Cui |
| author_facet | Ming Zhang Demin Liu Qian Wang Xue Geng Qian Hou Guoqiang Gu Ruiqin Xie Wei Cui |
| author_sort | Ming Zhang |
| collection | DOAJ |
| description | Objective: Although the early use of a risk stratification score in gastrointestinal bleeding (GIB) is recommended, so far there has been no risk score for GIB in patients admitted to the cardiology department. To describe the risk factors of GIB and develop a new risk score model in patients admitted to the cardiology department. Methods: A total of 633 inpatients with GIB from January 2014 to December 2018 were recruited, 4,231 inpatients with non-GIB were recruited as the control group. Multivariate logistic regression was used to describe the risk factors of GIB. A new risk score model was developed in the derivation cohort. Accuracy to predict GIB was assessed by the area under the receiver operating characteristic (AUROC) curve in the validation cohort. Results: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin, and alanine aminotransferase (ALT) were associated with GIB. The model had a high predictive accuracy (AUROC 0.816 and 95% CI, 0.792-0.839), which was supported by the validation cohort (AUROC 0.841 and 95% CI, 0.807~0.874). Besides, the prediction of the model was better than HAS-BLED score (AUROC 0.557; 95% CI, 0.513~0.602) and CRUSADE score (AUROC 0.791; 95%CI, 0.757~0.825), respectively. Among the inpatients with a score of 0-3, 4-7, and ≥8 points, the incidence of GIB, the proportion of inpatients requiring suspended red blood cells transfusion, length of stay, and in-hospital mortality all increased gradually (P< 0.001). Conclusions: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin, and ALT are associated with GIB. The new risk score model is an accurate risk score that predicts GIB in patients admitted to the cardiology department. |
| first_indexed | 2024-12-13T21:44:57Z |
| format | Article |
| id | doaj.art-2fa74a68f133456d84898c5b255e541a |
| institution | Directory Open Access Journal |
| issn | 1109-9666 |
| language | English |
| last_indexed | 2024-12-13T21:44:57Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hellenic Journal of Cardiology |
| spelling | doaj.art-2fa74a68f133456d84898c5b255e541a2022-12-21T23:30:26ZengElsevierHellenic Journal of Cardiology1109-96662021-07-01624291296Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk scoreMing Zhang0Demin Liu1Qian Wang2Xue Geng3Qian Hou4Guoqiang Gu5Ruiqin Xie6Wei Cui7Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaCorrespondence. The Second Hospital of Hebei Medical University and Institute of Cardiocerebrovascular Disease of Hebei Province, No. 215, He Ping West Road, Shijiazhuang, 050000, China.; Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR ChinaObjective: Although the early use of a risk stratification score in gastrointestinal bleeding (GIB) is recommended, so far there has been no risk score for GIB in patients admitted to the cardiology department. To describe the risk factors of GIB and develop a new risk score model in patients admitted to the cardiology department. Methods: A total of 633 inpatients with GIB from January 2014 to December 2018 were recruited, 4,231 inpatients with non-GIB were recruited as the control group. Multivariate logistic regression was used to describe the risk factors of GIB. A new risk score model was developed in the derivation cohort. Accuracy to predict GIB was assessed by the area under the receiver operating characteristic (AUROC) curve in the validation cohort. Results: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin, and alanine aminotransferase (ALT) were associated with GIB. The model had a high predictive accuracy (AUROC 0.816 and 95% CI, 0.792-0.839), which was supported by the validation cohort (AUROC 0.841 and 95% CI, 0.807~0.874). Besides, the prediction of the model was better than HAS-BLED score (AUROC 0.557; 95% CI, 0.513~0.602) and CRUSADE score (AUROC 0.791; 95%CI, 0.757~0.825), respectively. Among the inpatients with a score of 0-3, 4-7, and ≥8 points, the incidence of GIB, the proportion of inpatients requiring suspended red blood cells transfusion, length of stay, and in-hospital mortality all increased gradually (P< 0.001). Conclusions: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin, and ALT are associated with GIB. The new risk score model is an accurate risk score that predicts GIB in patients admitted to the cardiology department.http://www.sciencedirect.com/science/article/pii/S1109966620301639Gastrointestinal BleedingCardiologyRisk factorsRisk score |
| spellingShingle | Ming Zhang Demin Liu Qian Wang Xue Geng Qian Hou Guoqiang Gu Ruiqin Xie Wei Cui Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score Hellenic Journal of Cardiology Gastrointestinal Bleeding Cardiology Risk factors Risk score |
| title | Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score |
| title_full | Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score |
| title_fullStr | Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score |
| title_full_unstemmed | Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score |
| title_short | Gastrointestinal bleeding in patients admitted to cardiology: risk factors and a new risk score |
| title_sort | gastrointestinal bleeding in patients admitted to cardiology risk factors and a new risk score |
| topic | Gastrointestinal Bleeding Cardiology Risk factors Risk score |
| url | http://www.sciencedirect.com/science/article/pii/S1109966620301639 |
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