Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases

Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases

Autophagy is an intracellular degradation pathway for malfunctioning aggregation-prone proteins, damaged organelles, unwanted macromolecules and invading pathogens. This process is essential for maintaining cellular and tissue homeostasis that contribute to organismal survival. Autophagy dysfunction...

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Bibliographic Details
Main Authors: Prashanta Kumar Panda, Alexandra Fahrner, Somya Vats, Elena Seranova, Vartika Sharma, Miruna Chipara, Priyal Desai, Jorge Torresi, Tatiana Rosenstock, Dhiraj Kumar, Sovan Sarkar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
autophagy
autophagy reporter
autophagy substrate
autophagy modulator
screening method
neurodegenerative diseases
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00038/full

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