Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack
Objective. This study is aimed at exploring alteration in motor-related effective connectivity in individuals with transient ischemic attack (TIA). Methods. A total of 48 individuals with TIA and 41 age-matched and sex-matched healthy controls (HCs) were recruited for this study. The participants we...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/2219993 |
| _version_ | 1811186996320665600 |
|---|---|
| author | Zeqi Hao Yulin Song Yuyu Shi Hongyu Xi Hongqiang Zhang Mengqi Zhao Jiahao Yu Lina Huang Huayun Li |
| author_facet | Zeqi Hao Yulin Song Yuyu Shi Hongyu Xi Hongqiang Zhang Mengqi Zhao Jiahao Yu Lina Huang Huayun Li |
| author_sort | Zeqi Hao |
| collection | DOAJ |
| description | Objective. This study is aimed at exploring alteration in motor-related effective connectivity in individuals with transient ischemic attack (TIA). Methods. A total of 48 individuals with TIA and 41 age-matched and sex-matched healthy controls (HCs) were recruited for this study. The participants were scanned using MRI, and their clinical characteristics were collected. To investigate motor-related effective connectivity differences between individuals with TIA and HCs, the bilateral primary motor cortex (M1) was used as the regions of interest (ROIs) to perform a whole-brain Granger causality analysis (GCA). Furthermore, partial correlation was used to evaluate the relationship between GCA values and the clinical characteristics of individuals with TIA. Results. Compared with HCs, individuals with TIA demonstrated alterations in the effective connectivity between M1 and widely distributed brain regions involved in motor, visual, auditory, and sensory integration. In addition, GCA values were significantly correlated with high- and low-density lipoprotein cholesterols in individuals with TIA. Conclusion. This study provides important evidence for the alteration of motor-related effective connectivity in TIA, which reflects the abnormal information flow between different brain regions. This could help further elucidate the pathological mechanisms of motor impairment in individuals with TIA and provide a new perspective for future early diagnosis and intervention for TIA. |
| first_indexed | 2024-04-11T13:55:44Z |
| format | Article |
| id | doaj.art-2fa9d8c7ba37403dbc51455bfb3254bf |
| institution | Directory Open Access Journal |
| issn | 1687-5443 |
| language | English |
| last_indexed | 2024-04-11T13:55:44Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj.art-2fa9d8c7ba37403dbc51455bfb3254bf2022-12-22T04:20:21ZengHindawi LimitedNeural Plasticity1687-54432022-01-01202210.1155/2022/2219993Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic AttackZeqi Hao0Yulin Song1Yuyu Shi2Hongyu Xi3Hongqiang Zhang4Mengqi Zhao5Jiahao Yu6Lina Huang7Huayun Li8School of Teacher EducationDepartment of NeurologySchool of Teacher EducationFaculty of Western LanguagesDepartment of RadiologySchool of Teacher EducationSchool of Teacher EducationDepartment of RadiologySchool of Teacher EducationObjective. This study is aimed at exploring alteration in motor-related effective connectivity in individuals with transient ischemic attack (TIA). Methods. A total of 48 individuals with TIA and 41 age-matched and sex-matched healthy controls (HCs) were recruited for this study. The participants were scanned using MRI, and their clinical characteristics were collected. To investigate motor-related effective connectivity differences between individuals with TIA and HCs, the bilateral primary motor cortex (M1) was used as the regions of interest (ROIs) to perform a whole-brain Granger causality analysis (GCA). Furthermore, partial correlation was used to evaluate the relationship between GCA values and the clinical characteristics of individuals with TIA. Results. Compared with HCs, individuals with TIA demonstrated alterations in the effective connectivity between M1 and widely distributed brain regions involved in motor, visual, auditory, and sensory integration. In addition, GCA values were significantly correlated with high- and low-density lipoprotein cholesterols in individuals with TIA. Conclusion. This study provides important evidence for the alteration of motor-related effective connectivity in TIA, which reflects the abnormal information flow between different brain regions. This could help further elucidate the pathological mechanisms of motor impairment in individuals with TIA and provide a new perspective for future early diagnosis and intervention for TIA.http://dx.doi.org/10.1155/2022/2219993 |
| spellingShingle | Zeqi Hao Yulin Song Yuyu Shi Hongyu Xi Hongqiang Zhang Mengqi Zhao Jiahao Yu Lina Huang Huayun Li Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack Neural Plasticity |
| title | Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack |
| title_full | Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack |
| title_fullStr | Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack |
| title_full_unstemmed | Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack |
| title_short | Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack |
| title_sort | altered effective connectivity of the primary motor cortex in transient ischemic attack |
| url | http://dx.doi.org/10.1155/2022/2219993 |
| work_keys_str_mv | AT zeqihao alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT yulinsong alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT yuyushi alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT hongyuxi alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT hongqiangzhang alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT mengqizhao alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT jiahaoyu alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT linahuang alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack AT huayunli alteredeffectiveconnectivityoftheprimarymotorcortexintransientischemicattack |