The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis
The article provides an overview of scientific research to explain the mechanisms of inefficient implementation of antigen-specific immune response in patients with tuberculosis infection depending on the clinical form (infiltrative and disseminated pulmonary tuberculosis) and the course (drug-sensi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2017-01-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/746 |
| _version_ | 1797872879918907392 |
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| author | E. G. Churina O. I. Urazova V. V. Novitskiy I. Ye. Yesimova T. Ye. Kononova O. V. Filinyuk Yu. V. Kolobovnikova A. I. Dmitrieva |
| author_facet | E. G. Churina O. I. Urazova V. V. Novitskiy I. Ye. Yesimova T. Ye. Kononova O. V. Filinyuk Yu. V. Kolobovnikova A. I. Dmitrieva |
| author_sort | E. G. Churina |
| collection | DOAJ |
| description | The article provides an overview of scientific research to explain the mechanisms of inefficient implementation of antigen-specific immune response in patients with tuberculosis infection depending on the clinical form (infiltrative and disseminated pulmonary tuberculosis) and the course (drug-sensitive and drug-resistant pulmonary tuberculosis) of the disease. The mechanisms of immune imbalance in patients with pulmonary tuberculosis are associated with abnormal co-stimulation of a signal required for the activation of T-lymphocytes and immunosuppressive influence of regulatory T-cells both when they interact with dendritic cells at the inductive stage of the immune response, and in the process of differentiation and proliferation of effector cells with formation of suppressive mode of immune-regulation. |
| first_indexed | 2024-04-10T01:07:15Z |
| format | Article |
| id | doaj.art-2fa9e355c8844531b481103a723eb76f |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:07:15Z |
| publishDate | 2017-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-2fa9e355c8844531b481103a723eb76f2023-03-13T09:58:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842017-01-0115516617710.20538/1682-0363-2016-5-166-177612The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosisE. G. Churina0O. I. Urazova1V. V. Novitskiy2I. Ye. Yesimova3T. Ye. Kononova4O. V. Filinyuk5Yu. V. Kolobovnikova6A. I. Dmitrieva7Сибирский государственный медицинский университет; Национальный исследовательский Томский государственный университет (НИ ТГУ)Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетThe article provides an overview of scientific research to explain the mechanisms of inefficient implementation of antigen-specific immune response in patients with tuberculosis infection depending on the clinical form (infiltrative and disseminated pulmonary tuberculosis) and the course (drug-sensitive and drug-resistant pulmonary tuberculosis) of the disease. The mechanisms of immune imbalance in patients with pulmonary tuberculosis are associated with abnormal co-stimulation of a signal required for the activation of T-lymphocytes and immunosuppressive influence of regulatory T-cells both when they interact with dendritic cells at the inductive stage of the immune response, and in the process of differentiation and proliferation of effector cells with formation of suppressive mode of immune-regulation.https://bulletin.ssmu.ru/jour/article/view/746туберкулез легкихиммунный ответрегуляторные т-клеткииммунорегуляция |
| spellingShingle | E. G. Churina O. I. Urazova V. V. Novitskiy I. Ye. Yesimova T. Ye. Kononova O. V. Filinyuk Yu. V. Kolobovnikova A. I. Dmitrieva The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis Бюллетень сибирской медицины туберкулез легких иммунный ответ регуляторные т-клетки иммунорегуляция |
| title | The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis |
| title_full | The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis |
| title_fullStr | The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis |
| title_full_unstemmed | The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis |
| title_short | The factors of dysregualtion of the immune response (at different stage of its implementation) in patients with pulmonary tuberculosis |
| title_sort | factors of dysregualtion of the immune response at different stage of its implementation in patients with pulmonary tuberculosis |
| topic | туберкулез легких иммунный ответ регуляторные т-клетки иммунорегуляция |
| url | https://bulletin.ssmu.ru/jour/article/view/746 |
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