Fructose Metabolism in Cancer
The interest in fructose metabolism is based on the observation that an increased dietary fructose consumption leads to an increased risk of obesity and metabolic syndrome. In particular, obesity is a known risk factor to develop many types of cancer and there is clinical and experimental evidence t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2635 |
| _version_ | 1797545408916881408 |
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| author | Nils Krause Andre Wegner |
| author_facet | Nils Krause Andre Wegner |
| author_sort | Nils Krause |
| collection | DOAJ |
| description | The interest in fructose metabolism is based on the observation that an increased dietary fructose consumption leads to an increased risk of obesity and metabolic syndrome. In particular, obesity is a known risk factor to develop many types of cancer and there is clinical and experimental evidence that an increased fructose intake promotes cancer growth. The precise mechanism, however, in which fructose induces tumor growth is still not fully understood. In this article, we present an overview of the metabolic pathways that utilize fructose and how fructose metabolism can sustain cancer cell proliferation. Although the degradation of fructose shares many of the enzymes and metabolic intermediates with glucose metabolism through glycolysis, glucose and fructose are metabolized differently. We describe the different metabolic fates of fructose carbons and how they are connected to lipogenesis and nucleotide synthesis. In addition, we discuss how the endogenous production of fructose from glucose via the polyol pathway can be beneficial for cancer cells. |
| first_indexed | 2024-03-10T14:14:22Z |
| format | Article |
| id | doaj.art-2faa9760400b43e3a8f9d652c0ecdeb5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:14:22Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2faa9760400b43e3a8f9d652c0ecdeb52023-11-20T23:51:53ZengMDPI AGCells2073-44092020-12-01912263510.3390/cells9122635Fructose Metabolism in CancerNils Krause0Andre Wegner1Department of Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, 38106 Braunschweig, GermanyDepartment of Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, 38106 Braunschweig, GermanyThe interest in fructose metabolism is based on the observation that an increased dietary fructose consumption leads to an increased risk of obesity and metabolic syndrome. In particular, obesity is a known risk factor to develop many types of cancer and there is clinical and experimental evidence that an increased fructose intake promotes cancer growth. The precise mechanism, however, in which fructose induces tumor growth is still not fully understood. In this article, we present an overview of the metabolic pathways that utilize fructose and how fructose metabolism can sustain cancer cell proliferation. Although the degradation of fructose shares many of the enzymes and metabolic intermediates with glucose metabolism through glycolysis, glucose and fructose are metabolized differently. We describe the different metabolic fates of fructose carbons and how they are connected to lipogenesis and nucleotide synthesis. In addition, we discuss how the endogenous production of fructose from glucose via the polyol pathway can be beneficial for cancer cells.https://www.mdpi.com/2073-4409/9/12/2635fructose metabolismcancer metabolismpolyol pathwaypentose phosphate pathwaylipogenesisAKR1B1 |
| spellingShingle | Nils Krause Andre Wegner Fructose Metabolism in Cancer Cells fructose metabolism cancer metabolism polyol pathway pentose phosphate pathway lipogenesis AKR1B1 |
| title | Fructose Metabolism in Cancer |
| title_full | Fructose Metabolism in Cancer |
| title_fullStr | Fructose Metabolism in Cancer |
| title_full_unstemmed | Fructose Metabolism in Cancer |
| title_short | Fructose Metabolism in Cancer |
| title_sort | fructose metabolism in cancer |
| topic | fructose metabolism cancer metabolism polyol pathway pentose phosphate pathway lipogenesis AKR1B1 |
| url | https://www.mdpi.com/2073-4409/9/12/2635 |
| work_keys_str_mv | AT nilskrause fructosemetabolismincancer AT andrewegner fructosemetabolismincancer |