Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Summary: Background: Crimean-Congo hemorrhagic fever virus is the cause of a severe hemorrhagic fever with cases reported throughout a wide-geographic region. Spread by the bite of infected ticks, contact with infected livestock or in the health care setting, disease begins as a non-specific febril...

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Bibliographic Details
Main Authors: Shanna S. Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H. Erasmus, Heinz Feldmann, David W. Hawman
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
Crimean-Congo hemorrhagic fever
CCHFV
Vaccine
RNA vaccine
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003693

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http://www.sciencedirect.com/science/article/pii/S2352396422003693

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