Mechanisms of Coronary Artery Spasm
Recent clinical trials have highlighted that percutaneous coronary intervention in patients with stable angina provides limited additional benefits on top of optimal medical therapy. This has led to much more attention being paid to coronary vasomotion abnormalities regardless of obstructive or non-...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2023-05-01
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| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articleindex/ecr.2022.55 |
| _version_ | 1826933115881259008 |
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| author | Kensuke Nishimiya Jun Takahashi Kazuma Oyama Yasuharu Matsumoto Satoshi Yasuda Hiroaki Shimokawa |
| author_facet | Kensuke Nishimiya Jun Takahashi Kazuma Oyama Yasuharu Matsumoto Satoshi Yasuda Hiroaki Shimokawa |
| author_sort | Kensuke Nishimiya |
| collection | DOAJ |
| description | Recent clinical trials have highlighted that percutaneous coronary intervention in patients with stable angina provides limited additional benefits on top of optimal medical therapy. This has led to much more attention being paid to coronary vasomotion abnormalities regardless of obstructive or non-obstructive arterial segments. Coronary vasomotion is regulated by multiple mechanisms that include the endothelium, vascular smooth muscle cells (VSMCs), myocardial metabolic demand, autonomic nervous system and inflammation. Over the years, several animal models have been developed to explore the central mechanism of coronary artery spasm. This review summarises the landmark studies on the mechanisms of coronary vasospasm demonstrating the central role of Rho-kinase as a molecular switch of VSMC hypercontraction and the important role of coronary adventitial inflammation for Rho-kinase upregulation in VSMCs. |
| first_indexed | 2024-03-07T17:39:45Z |
| format | Article |
| id | doaj.art-2fab9db6cdaf44169c840afd0dcfbc3e |
| institution | Directory Open Access Journal |
| issn | 1758-3756 1758-3764 |
| language | English |
| last_indexed | 2025-02-17T17:26:51Z |
| publishDate | 2023-05-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj.art-2fab9db6cdaf44169c840afd0dcfbc3e2024-12-14T16:04:26ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642023-05-011810.15420/ecr.2022.55Mechanisms of Coronary Artery SpasmKensuke Nishimiya0Jun Takahashi1Kazuma Oyama2Yasuharu Matsumoto3Satoshi Yasuda4Hiroaki Shimokawa5Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanRecent clinical trials have highlighted that percutaneous coronary intervention in patients with stable angina provides limited additional benefits on top of optimal medical therapy. This has led to much more attention being paid to coronary vasomotion abnormalities regardless of obstructive or non-obstructive arterial segments. Coronary vasomotion is regulated by multiple mechanisms that include the endothelium, vascular smooth muscle cells (VSMCs), myocardial metabolic demand, autonomic nervous system and inflammation. Over the years, several animal models have been developed to explore the central mechanism of coronary artery spasm. This review summarises the landmark studies on the mechanisms of coronary vasospasm demonstrating the central role of Rho-kinase as a molecular switch of VSMC hypercontraction and the important role of coronary adventitial inflammation for Rho-kinase upregulation in VSMCs.https://www.ecrjournal.com/articleindex/ecr.2022.55 |
| spellingShingle | Kensuke Nishimiya Jun Takahashi Kazuma Oyama Yasuharu Matsumoto Satoshi Yasuda Hiroaki Shimokawa Mechanisms of Coronary Artery Spasm European Cardiology Review |
| title | Mechanisms of Coronary Artery Spasm |
| title_full | Mechanisms of Coronary Artery Spasm |
| title_fullStr | Mechanisms of Coronary Artery Spasm |
| title_full_unstemmed | Mechanisms of Coronary Artery Spasm |
| title_short | Mechanisms of Coronary Artery Spasm |
| title_sort | mechanisms of coronary artery spasm |
| url | https://www.ecrjournal.com/articleindex/ecr.2022.55 |
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