Effects of different ablation points of renal denervation on the efficacy of resistant hypertension
Objective To explore the blood pressure response to different ablation points of renal denervation (RDN) in patients with resistant hypertension Methods A total of 42 cases with resistant hypertension treated by RDN in our center from 2013 to 2015 were retrospectively analyzed. The patients were div...
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PeerJ Inc.
2020-09-01
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| author | Hua Zhang Ling-Yan Li Rong-Xue Xiao Ting-Chuan Zhang Zong-Jun Liu Jun-Qing Gao |
| author_facet | Hua Zhang Ling-Yan Li Rong-Xue Xiao Ting-Chuan Zhang Zong-Jun Liu Jun-Qing Gao |
| author_sort | Hua Zhang |
| collection | DOAJ |
| description | Objective To explore the blood pressure response to different ablation points of renal denervation (RDN) in patients with resistant hypertension Methods A total of 42 cases with resistant hypertension treated by RDN in our center from 2013 to 2015 were retrospectively analyzed. The patients were divided into two groups according to the different ablation points of RDN: the standard treatment group (spiral ablation from near to proximal, with less than 8 points per artery) and the intensive treatment group (from near to far by spiral ablation, with at least 8 points per artery), with 21 patients in each group. The ablation parameters, including points, impedance, actual wattage, and actual temperature, were recorded intraoperatively. Renal angiography was performed again after RDN. Ambulatory blood pressure (ABP) images were taken for all patients at the baseline and 6 months after operation. Results The mean 24-h blood pressure of the standard treatment group was lower than that of the baseline (24-h systolic blood pressure decreased by 7.4 ± 10.6 mmHg and 24-h diastolic blood pressure decreased by 4.6 ± 6.1 mmHg), and the mean 24-h blood pressure decreased significantly from baseline to 6 months in the intensive treatment group (24–h systolic blood pressure decreased by 27.4 ± 11.4 mmHg, P < 0.0001; 24–h diastolic blood pressure decreased by 10.9 ± 9.6 mmHg, P = 0.005). There was a positive correlation between the decrease of systolic/diastolic 24-hour mean and the number of ablation points used in the procedure. The mean value of systolic and diastolic blood pressure was positively correlated with ablation points at 24-hour (R2 = 0.777 and 0.633 respectively, P < 0.01). There were no adverse events in either group after the operation and during the follow-up. Conclusions RDN could significantly reduce BP in patients with resistant hypertension. Our study showed that the antihypertensive effect appeared to be positively correlated with the number of ablation points. |
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| language | English |
| last_indexed | 2024-03-09T06:43:09Z |
| publishDate | 2020-09-01 |
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| spelling | doaj.art-2fac3dd3f8944edf8feb8430d998d6792023-12-03T10:41:53ZengPeerJ Inc.PeerJ2167-83592020-09-018e984210.7717/peerj.9842Effects of different ablation points of renal denervation on the efficacy of resistant hypertensionHua Zhang0Ling-Yan Li1Rong-Xue Xiao2Ting-Chuan Zhang3Zong-Jun Liu4Jun-Qing Gao5Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Putuo Center Clinical College, Anhui Medical University, Shanghai, ChinaDepartment of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Putuo Center Clinical College, Anhui Medical University, Shanghai, ChinaDepartment of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaObjective To explore the blood pressure response to different ablation points of renal denervation (RDN) in patients with resistant hypertension Methods A total of 42 cases with resistant hypertension treated by RDN in our center from 2013 to 2015 were retrospectively analyzed. The patients were divided into two groups according to the different ablation points of RDN: the standard treatment group (spiral ablation from near to proximal, with less than 8 points per artery) and the intensive treatment group (from near to far by spiral ablation, with at least 8 points per artery), with 21 patients in each group. The ablation parameters, including points, impedance, actual wattage, and actual temperature, were recorded intraoperatively. Renal angiography was performed again after RDN. Ambulatory blood pressure (ABP) images were taken for all patients at the baseline and 6 months after operation. Results The mean 24-h blood pressure of the standard treatment group was lower than that of the baseline (24-h systolic blood pressure decreased by 7.4 ± 10.6 mmHg and 24-h diastolic blood pressure decreased by 4.6 ± 6.1 mmHg), and the mean 24-h blood pressure decreased significantly from baseline to 6 months in the intensive treatment group (24–h systolic blood pressure decreased by 27.4 ± 11.4 mmHg, P < 0.0001; 24–h diastolic blood pressure decreased by 10.9 ± 9.6 mmHg, P = 0.005). There was a positive correlation between the decrease of systolic/diastolic 24-hour mean and the number of ablation points used in the procedure. The mean value of systolic and diastolic blood pressure was positively correlated with ablation points at 24-hour (R2 = 0.777 and 0.633 respectively, P < 0.01). There were no adverse events in either group after the operation and during the follow-up. Conclusions RDN could significantly reduce BP in patients with resistant hypertension. Our study showed that the antihypertensive effect appeared to be positively correlated with the number of ablation points.https://peerj.com/articles/9842.pdfAblation pointsResistant hypertension |
| spellingShingle | Hua Zhang Ling-Yan Li Rong-Xue Xiao Ting-Chuan Zhang Zong-Jun Liu Jun-Qing Gao Effects of different ablation points of renal denervation on the efficacy of resistant hypertension PeerJ Ablation points Resistant hypertension |
| title | Effects of different ablation points of renal denervation on the efficacy of resistant hypertension |
| title_full | Effects of different ablation points of renal denervation on the efficacy of resistant hypertension |
| title_fullStr | Effects of different ablation points of renal denervation on the efficacy of resistant hypertension |
| title_full_unstemmed | Effects of different ablation points of renal denervation on the efficacy of resistant hypertension |
| title_short | Effects of different ablation points of renal denervation on the efficacy of resistant hypertension |
| title_sort | effects of different ablation points of renal denervation on the efficacy of resistant hypertension |
| topic | Ablation points Resistant hypertension |
| url | https://peerj.com/articles/9842.pdf |
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