Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a

Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a

Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms that contribute to BMSC senescence is critica...

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Bibliographic Details
Main Authors: Yong Zheng, Shangrong Wu, Haiqiang Ke, Shanshan Peng, Chengjun Hu
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Experimental Gerontology
Subjects:
Bone marrow mesenchymal stem cells
Senescence
Autophagy
Interleukin 6
Interleukin 8
FoxO3a
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556522003710

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