Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT
It has been shown that patients with heart failure have high levels of brain or type B natriuretic peptide (BNP), and that there is a correlation between these and the severity of their condition. Many studies report that monitoring BNP levels could be a sensitive method for diagnosing heart failure...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2016-08-01
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| Series: | Egyptian Journal of Critical Care Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090730316300251 |
| _version_ | 1797282680153309184 |
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| author | Amr Nawar Wael Samy Hisham Elaasar Amal Rizk Sherif Mokhtar |
| author_facet | Amr Nawar Wael Samy Hisham Elaasar Amal Rizk Sherif Mokhtar |
| author_sort | Amr Nawar |
| collection | DOAJ |
| description | It has been shown that patients with heart failure have high levels of brain or type B natriuretic peptide (BNP), and that there is a correlation between these and the severity of their condition. Many studies report that monitoring BNP levels could be a sensitive method for diagnosing heart failure and performing risk stratification, and that they could act as an independent predictor of adverse events helping clinicians arrive at a prognosis.
To achieve this purpose we studied 30 patients with CHF (27 males, mean age 57 years) undergoing CRT implantation.
The main finding of our study was that CRT exerted a substantial reduction in plasma BNP levels among responders, but no significant change in nonresponders after 3 months follow-up, only responders showed a significant decrease in plasma BNP levels (229.64 pg/ml ± 111) as compared to non-responders (468 pg/ml ± 96) P value <0.01. Response could be predicted with a cut-off value of 360 pg/ml, with a sensitivity and specificity of 90.9% and 87.5%, respectively.
In conclusion, BNP monitoring is potentially a good prognostic indicator of LV functional recovery and reverse remodeling after CRT can accurately identify echocardiographic responders after CRT. Percentage change in plasma BNP levels from baseline to 3 months was the strongest predictor of long-term response to CRT and may have potential to predict outcome. |
| first_indexed | 2024-03-07T17:17:53Z |
| format | Article |
| id | doaj.art-2fad050630ae41a596092d6fc8f085ad |
| institution | Directory Open Access Journal |
| issn | 2090-7303 |
| language | English |
| last_indexed | 2024-03-07T17:17:53Z |
| publishDate | 2016-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Egyptian Journal of Critical Care Medicine |
| spelling | doaj.art-2fad050630ae41a596092d6fc8f085ad2024-03-02T21:42:46ZengSpringerEgyptian Journal of Critical Care Medicine2090-73032016-08-01429710310.1016/j.ejccm.2016.05.003Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRTAmr NawarWael SamyHisham ElaasarAmal RizkSherif MokhtarIt has been shown that patients with heart failure have high levels of brain or type B natriuretic peptide (BNP), and that there is a correlation between these and the severity of their condition. Many studies report that monitoring BNP levels could be a sensitive method for diagnosing heart failure and performing risk stratification, and that they could act as an independent predictor of adverse events helping clinicians arrive at a prognosis. To achieve this purpose we studied 30 patients with CHF (27 males, mean age 57 years) undergoing CRT implantation. The main finding of our study was that CRT exerted a substantial reduction in plasma BNP levels among responders, but no significant change in nonresponders after 3 months follow-up, only responders showed a significant decrease in plasma BNP levels (229.64 pg/ml ± 111) as compared to non-responders (468 pg/ml ± 96) P value <0.01. Response could be predicted with a cut-off value of 360 pg/ml, with a sensitivity and specificity of 90.9% and 87.5%, respectively. In conclusion, BNP monitoring is potentially a good prognostic indicator of LV functional recovery and reverse remodeling after CRT can accurately identify echocardiographic responders after CRT. Percentage change in plasma BNP levels from baseline to 3 months was the strongest predictor of long-term response to CRT and may have potential to predict outcome.http://www.sciencedirect.com/science/article/pii/S2090730316300251BNPCRTHeart failure |
| spellingShingle | Amr Nawar Wael Samy Hisham Elaasar Amal Rizk Sherif Mokhtar Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT Egyptian Journal of Critical Care Medicine BNP CRT Heart failure |
| title | Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
| title_full | Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
| title_fullStr | Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
| title_full_unstemmed | Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
| title_short | Usefulness of plasma B type natriuretic peptide as a predictor to identify responders following CRT |
| title_sort | usefulness of plasma b type natriuretic peptide as a predictor to identify responders following crt |
| topic | BNP CRT Heart failure |
| url | http://www.sciencedirect.com/science/article/pii/S2090730316300251 |
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